Protein Alignment AstA-R1 and Ptgdr2

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_001012070.1
• Gene: Ptgdr2 / 309212
• RGDID: 1311986
• Length: 403
• Species: Rattus norvegicus
• Alignment Length: 333
• Identity: 85/333 - (25%)
• Similarity: 141/333 - (42%)
• Gaps: 63/333 - (18%)

  Fly    54 HNANDSMEY-DAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRST-TNLLIINL 116
            :::|.|:.| |..||.|.           |:....||:.|||::.||  ..:||.| ....:::|
  Rat    21 NHSNSSLRYIDHVSVLLH-----------GLASLLGLVENGLILFVV--GCRMRQTVVTTWVLHL 72

  Fly   117 AVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVT 181
            |:||:|.......||....|...|..|..:||....:..:....|.:.|..:|.||.|.||.||.
  Rat    73 ALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVW 137

  Fly   182 SMSLRTERNATLAIMCAWITIVTTAIPVALSHSV------RIYQYHG----NAG----TACVFST 232
            :.:.||...|....:..|...|...:|..:....      ||..|:.    |.|    |.|.:..
  Rat   138 AQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQ 202

  Fly   233 EEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRV---TRMVV 294
            :       ...||.||.:::.||.:|...::.:..:|            ..:|::|.   .|:|.
  Rat   203 K-------ALAVSKFLLAFMVPLAIIASSHVAVSLQL------------HHRGRQRTGRFVRLVA 248

  Fly   295 VVVLAFAICWLPIHVILVLKALNLYGGSH-LSVIIQIISH------VVAYTNSCINPILYAFLSD 352
            .:|:||.:||.|.|:..:|:|     .:| ::.:.|:.|.      .:|:.||.:||:||.....
  Rat   249 AIVVAFILCWGPYHIFSLLEA-----RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCP 308

  Fly   353 NFRKAFRK 360
            :.....|:
  Rat   309 DMLHKLRR 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	77/307 (25%)
		TM helix 1	76..102	CDD:320224	8/25 (32%)
		TM helix 2	109..135	CDD:320224	7/25 (28%)
		TM helix 3	147..177	CDD:320224	8/29 (28%)
		TM helix 4	189..209	CDD:320224	3/19 (16%)
		TM helix 5	239..268	CDD:320224	7/28 (25%)
		TM helix 6	284..314	CDD:320224	11/32 (34%)
		TM helix 7	326..351	CDD:320224	9/30 (30%)
Ptgdr2	NP_001012070.1	7tm_GPCRs	32..314	CDD:475119	80/318 (25%)
		TM helix 1	34..58	CDD:410628	11/36 (31%)
		TM helix 2	66..87	CDD:410628	5/20 (25%)
		TM helix 3	104..126	CDD:410628	3/21 (14%)
		TM helix 4	149..165	CDD:410628	2/15 (13%)
		TM helix 5	203..226	CDD:410628	7/29 (24%)
		TM helix 6	244..266	CDD:410628	9/21 (43%)
		TM helix 7	282..307	CDD:410628	8/24 (33%)
		Involved in the recycling of CRTH2. /evidence=ECO:0000250	329..332
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..403