DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Gpr15

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001099360.1	Gene:	Gpr15 / 288181	RGDID:	1306639	Length:	360	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	92/343 - (26%)
Similarity:	154/343 - (44%)	Gaps:	45/343 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 YDA--------ESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAV 118
            |||        |:.:.....|..:|||:..:...|:|||.::::.:....:.|...::.|||||.
  Rat    13 YDATSPDPRIMETPSHTSYTSVFLPVFYTAVFLTGVLGNFILMVTLHFKHRNRRLIDIFIINLAA 77

  Fly   119 SDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSM 183
            ||.:|::....:...:..|..|..|::.||...|.|.|..||:|:.|..||.||:||::.|..:.
  Rat    78 SDFIFLVTLPLWVDKEASLGLWRTGSLLCKGSSYTISVNMHCNVFLLTCMSMDRYLAIMRPTLAR 142

  Fly   184 SLRTERNATLAIMCA--WITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEEI---WSLVGFQ 243
            .|| .|:...|: ||  ||......:|..||..:.    |......|.......:   |.||...
  Rat   143 RLR-RRSCAYAV-CAVIWIISCLLGLPTLLSRGLT----HIEGKPYCAEKKPTSLKLMWGLVALI 201

  Fly   244 VSFFLSSYVAPLTLICFLYMGMLARLWKSAPGC---KPSAESRKGKRRVTRMVVVVVLAFAICWL 305
            .:||:     ||..|...|..:..||      |   :.|.:..|..|:..:::|:||.||.|.|:
  Rat   202 ATFFV-----PLLSIVSSYCCITRRL------CAHYQQSGKHNKKLRKSIKIIVIVVAAFTISWV 255

  Fly   306 PIHVILVLKAL------NLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWC 364
            |.:.:.:|..:      :.:....|...:::... :|:.|||:||:||.......|:|..:.: |
  Rat   256 PFNTVKLLAIVSGLQPESQFPSESLQQAMKVTGS-LAFANSCVNPLLYYIFDSYIRRAIVRSL-C 318

  Fly   365 GSPPPLMTNQQVTKTTRT 382
                |.:....:..:|.|
  Rat   319 ----PCLKIHNIGSSTET 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	46/161 (29%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	74/269 (28%)
Gpr15	NP_001099360.1	7tm_GPCRs	34..313	CDD:421689	82/296 (28%)
		TM helix 1	35..61	CDD:410628	7/25 (28%)
		TM helix 2	68..93	CDD:410628	8/24 (33%)
		TM helix 3	106..136	CDD:410628	15/29 (52%)
		TM helix 4	150..168	CDD:410628	5/18 (28%)
		TM helix 5	192..221	CDD:410628	9/33 (27%)
		TM helix 6	234..264	CDD:410628	10/29 (34%)
		TM helix 7	281..306	CDD:410628	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000