Protein Alignment AstA-R1 and MLNR

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_001498.1
• Gene: MLNR / 2862
• HGNCID: 4495
• Length: 412
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 87/328 - (26%)
• Similarity: 152/328 - (46%)
• Gaps: 62/328 - (18%)

  Fly    88 GLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVL---PEWPFGNVWCKF 149
            |:.||.:.::::...:.||:||||.:.::||||:| ::..:||..  |.|   ..|.||.:.|:.
Human    52 GVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLL-ILLGLPFDL--YRLWRSRPWVFGPLLCRL 113

  Fly   150 VQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIP----VA 210
            ..|:.....:.::..:..:|.:|:||:..|:.:..|.|.|.....|...|...:.:|.|    |.
Human   114 SLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVG 178

  Fly   211 LSHSVRIYQYHGNAGTACVFS----TEEEIW-------------------------------SLV 240
            :.....|....|..|||.:.|    :...:|                               .|.
Human   179 VEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLG 243

  Fly   241 GFQVSFFLSS--YVAPLTLICFLYMGMLAR-LWKS-APGCKPSAESR-KGKRRVTRMVVVVVLAF 300
            ..:|..::::  :..|...:..|| |::.| ||.| .|...|:|..| :|.|:..|:::||||||
Human   244 ALRVMLWVTTAYFFLPFLCLSILY-GLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAF 307

  Fly   301 AICWLPIHV--ILVLKALN---LYGGSHLSVI-IQIISHVVAYTNSCINPILYAFLSDNFRKAFR 359
            .|||||.||  |:.:...:   :|...:.::: :|:.     |.::.||||||..:|..:|.|..
Human   308 IICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLF-----YLSASINPILYNLISKKYRAAAF 367

  Fly   360 KVV 362
            |::
Human   368 KLL 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	85/322 (26%)
		TM helix 1	76..102	CDD:320224	3/13 (23%)
		TM helix 2	109..135	CDD:320224	10/25 (40%)
		TM helix 3	147..177	CDD:320224	6/29 (21%)
		TM helix 4	189..209	CDD:320224	5/23 (22%)
		TM helix 5	239..268	CDD:320224	6/30 (20%)
		TM helix 6	284..314	CDD:320224	17/31 (55%)
		TM helix 7	326..351	CDD:320224	8/25 (32%)
MLNR	NP_001498.1	7tm_GPCRs	39..366	CDD:475119	85/322 (26%)
		TM helix 1	41..65	CDD:410628	3/12 (25%)
		TM helix 2	74..95	CDD:410628	9/21 (43%)
		TM helix 3	112..134	CDD:410628	1/21 (5%)
		TM helix 4	157..173	CDD:410628	3/15 (20%)
		TM helix 5	245..268	CDD:410628	4/23 (17%)
		TM helix 6	297..319	CDD:410628	14/21 (67%)
		TM helix 7	334..359	CDD:410628	8/29 (28%)