DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and MCHR1

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_005288.4	Gene:	MCHR1 / 2847	HGNCID:	4479	Length:	353	Species:	Homo sapiens

Alignment Length:	389	Identity:	109/389 - (28%)
Similarity:	167/389 - (42%)	Gaps:	48/389 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLATLISSWPKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVS 74
            |.|:|:.:.|.||..:.|..::.|..:..                 ...|:.|          ::
Human     3 LEASLLPTGPNASNTSDGPDNLTSAGSPP-----------------RTGSISY----------IN 40

  Fly    75 TIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTN---LLIINLAVSDILFVIFCVPFTATDYV 136
            .|:|..||.|...|::||..||..||...::....|   :.||||:|.|:||:: .:||.....:
Human    41 IIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLL-GMPFMIHQLM 104

  Fly   137 -LPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWI 200
             ...|.||...|..:..|...:...|.|.|..|:.||:||.|||::|...|....|||.|...|.
Human   105 GNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWA 169

  Fly   201 TIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGM 265
            ....:..||.|  ..|:..:.|.| ..|..........|..|.:..|..::..|..:|...|:.:
Human   170 LSFISITPVWL--YARLIPFPGGA-VGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI 231

  Fly   266 LARLWKS-APGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQ 329
            |.|:..| ||..:.|...|  .:||||..:.:.|.|.:||.|.:| |.|..|::...:...|.:.
Human   232 LQRMTSSVAPASQRSIRLR--TKRVTRTAIAICLVFFVCWAPYYV-LQLTQLSISRPTLTFVYLY 293

  Fly   330 IISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWCGSPPP-----LMTNQQVTKTTRTATGNGT 388
            ..:..:.|.|||:||.:|..|.:.|||   ::|....|..     .::|.|.....||.: .||
Human   294 NAAISLGYANSCLNPFVYIVLCETFRK---RLVLSVKPAAQGQLRAVSNAQTADEERTES-KGT 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	49/160 (31%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	80/260 (31%)
MCHR1	NP_005288.4	7tmA_MCHR1	41..322	CDD:320460	91/290 (31%)
		TM helix 1	43..67	CDD:320460	10/23 (43%)
		TM helix 2	79..100	CDD:320460	10/21 (48%)
		TM helix 3	117..139	CDD:320460	5/21 (24%)
		TM helix 4	162..178	CDD:320460	3/15 (20%)
		TM helix 5	206..229	CDD:320460	4/22 (18%)
		TM helix 6	255..277	CDD:320460	9/22 (41%)
		TM helix 7	290..315	CDD:320460	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010