DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and GPR17

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001154887.1	Gene:	GPR17 / 2840	HGNCID:	4471	Length:	367	Species:	Homo sapiens

Alignment Length:	337	Identity:	83/337 - (24%)
Similarity:	151/337 - (44%)	Gaps:	65/337 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AESVALERIVSTIVPVFFGIIGF-AGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFC 127
            ||....|..:..::...|.::.| ..|:||.|.:.:.:.:.:..:..|:.:::|||:|:..|:
Human    48 AEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVL-- 110

  Fly   128 VPFTATDYVLP----------EWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTS 182
                    |||          .||||.:.|:...::..:..:.|:|.|..:|.|||||:||||.|
Human   111 --------VLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKS 167

  Fly   183 MSLRTERNATLAIMCAWITIVTTAIPVALS-------HSVRIYQYHGNAGTACVFSTEEEIWSLV 240
            :.||....|.||....|:.:.....|:.:|       |:|...|         ::..:....:||
Human   168 LKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQ---------LYREKASHHALV 223

  Fly   241 GFQVSF---FLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAI 302
            ...|:|   |:::....|.:|..|..|:..              .::.|.:..||:.:|:..|.:
Human   224 SLAVAFTFPFITTVTCYLLIIRSLRQGLRV--------------EKRLKTKAVRMIAIVLAIFLV 274

  Fly   303 CWLPIHVILVLKALNL--YGGS----HLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKV 361
            |::|.||...:..|:.  :|.|    .:..:...|:..:...|..::||:|.|:::.||.|...:
Human   275 CFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNL 339

  Fly   362 VWCG----SPPP 369
            : ||    .|||
Human   340 L-CGKRLKGPPP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	44/174 (25%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	67/281 (24%)
GPR17	NP_001154887.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
GPR17	NP_001154887.1	7tm_1	76..325	CDD:278431	67/281 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910