Protein Alignment AstA-R1 and PRLHR

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_004239.2
• Gene: PRLHR / 2834
• HGNCID: 4464
• Length: 370
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 114/407 - (28%)
• Similarity: 191/407 - (46%)
• Gaps: 70/407 - (17%)

  Fly     1 MAGHQSLALLLATLISSWPKA--------SWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNAN 57
            ||...:....::.|.|..|.|        :..:.||||:......:...:
Human     1 MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPF--------------- 50

  Fly    58 DSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDIL 122
                   :|:.|...:..::.:.:.::...||:||.|::||:...:::.:.||.||.|||:||:|
Human    51 -------QSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVL 108

  Fly   123 FVIFCVPFTATDYVLPE-WPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPV-TSMSL 185
            ....|||.|......|. |.||...|..|.::..||.:.||:||..::.||::.:|||: ..:||
Human   109 MCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISL 173

  Fly   186 RTERNATLAIMCAWITIVTTAIPVAL--------SHSVRIYQYHGNAGTACVFSTEEEIWSLVGF 242
            |....|.|||   |......|:|.|:        .|.||:          |     ||.|.....
Human   174 RLSAYAVLAI---WALSAVLALPAAVHTYHVELKPHDVRL----------C-----EEFWGSQER 220

  Fly   243 QVSFF-----LSSYVAPLTLICFLYMGMLARLW-KSAPGCKPSAES---RKGKRRVTRMVVVVVL 298
            |...:     |.:|:.||.:|...|:.:..:|. :..|||...:::   |..:||...::||:|:
Human   221 QRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVV 285

  Fly   299 AFAICWLPIHVILVLKALNLYG-GSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRK-- 360
            .||:||||:||..:|:.|:.:. ..:...::|::.|.:|.:::|.||.:||:|.|:||:..||
Human   286 VFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLL 350

  Fly   361 VVWCGSPPPLMTNQQVT 377
            |.|.....|...|..|:
Human   351 VAWPRKIAPHGQNMTVS 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	95/302 (31%)
		TM helix 1	76..102	CDD:320224	7/25 (28%)
		TM helix 2	109..135	CDD:320224	14/25 (56%)
		TM helix 3	147..177	CDD:320224	10/29 (34%)
		TM helix 4	189..209	CDD:320224	6/19 (32%)
		TM helix 5	239..268	CDD:320224	7/33 (21%)
		TM helix 6	284..314	CDD:320224	13/29 (45%)
		TM helix 7	326..351	CDD:320224	8/24 (33%)
PRLHR	NP_004239.2	TM helix 4	175..196	CDD:320516	7/23 (30%)
		TM helix 5	222..251	CDD:320516	6/28 (21%)
		TM helix 6	271..301	CDD:320516	13/29 (45%)
		TM helix 7	314..339	CDD:320516	8/24 (33%)
		Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000269|PubMed:11641419	365..370		1/3 (33%)
		7tmA_PrRP_R	77..346	CDD:320516	93/286 (33%)
		TM helix 2	95..120	CDD:320516	14/24 (58%)
		TM helix 3	134..164	CDD:320516	10/29 (34%)