DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and CXCR3

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001136269.1	Gene:	CXCR3 / 2833	HGNCID:	4540	Length:	415	Species:	Homo sapiens

Alignment Length:	379	Identity:	97/379 - (25%)
Similarity:	175/379 - (46%)	Gaps:	73/379 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 FTSEHTDHSDHNAND-----------SMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVIL 97
            |:|.: |:.::.::.           |:.:|          ...:|..:.::...||||||.|..
Human    70 FSSSY-DYGENESDSCCTSPPCPQDFSLNFD----------RAFLPALYSLLFLLGLLGNGAVAA 123

  Fly    98 VVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSV 162
            |:::.:...|:|:..:::|||:|.|.|: .:|..|.|..: :|.||:..||....:..:..:...
Human   124 VLLSRRTALSSTDTFLLHLAVADTLLVL-TLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGA 186

  Fly   163 YTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIP----VALSHSVRIYQYHGN 223
            ..|..:||||:|.:||.............||..:..|...:..|:|    ::..|..|:     |
Human   187 LLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL-----N 246

  Fly   224 AGTACVFSTEEEIWSLVG---FQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKG 285
            | |.|.::..:     ||   .:|...::.::.||.::.:.|..:||.|..|           :|
Human   247 A-THCQYNFPQ-----VGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVS-----------RG 294

  Fly   286 KRRV--TRMVVVVVLAFAICWLPIHVILVLKALNLYGG--------SHLSVIIQIISHVVAYTNS 340
            :||:  .|:|||||:|||:||.|.|:::::..|...|.        |.:.|...:.|. :.|.:.
Human   295 QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSG-LGYMHC 358

  Fly   341 CINPILYAFLSDNFRKAFRKVVW-----CGSPPPLMTNQQVTKTTRTATGNGTS 389
            |:||:||||:...||:.    :|     .|.|......:|.:.:.|.::.:.||
Human   359 CLNPLLYAFVGVKFRER----MWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETS 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	43/160 (27%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	75/272 (28%)
CXCR3	NP_001136269.1	7tmA_CXCR3	101..376	CDD:341335	85/303 (28%)
		TM helix 1	101..128	CDD:341335	9/26 (35%)
		TM helix 2	135..160	CDD:341335	9/25 (36%)
		TM helix 3	171..201	CDD:341335	8/29 (28%)
		TM helix 4	213..235	CDD:341335	5/21 (24%)
		TM helix 5	259..288	CDD:341335	5/28 (18%)
		TM helix 6	295..325	CDD:341335	15/29 (52%)
		TM helix 7	344..369	CDD:341335	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910