DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstA-R1 and NPBWR1

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_005276.2	Gene:	NPBWR1 / 2831	HGNCID:	4522	Length:	328	Species:	Homo sapiens

Alignment Length:	363	Identity:	102/363 - (28%)
Similarity:	160/363 - (44%)	Gaps:	52/363 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ATLISSWPKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTI 76
            |:....||.   .|:|....:|.||:|                          ....|...::..
Human     4 ASFSEPWPA---NASGPDPALSCSNAS--------------------------TLAPLPAPLAVA 39

  Fly    77 VPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWP 141
            |||.:.:|...||.||..|:.|::...:|::.|||.|:|||::|.||.: .:|....|::|.:||
Human    40 VPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWP 103

  Fly   142 FGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSL--RTERNATLAIMCAWITIVT 204
            ||.:.||.:..:.......|:|.|.:||.||:|.|:....|..:  ||...|....:..|..:..
Human   104 FGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTL 168

  Fly   205 TAIPVALSHSVRIYQYHGNAGTACVFSTEEEIW--------SLVGFQVSFFLSSYVAPLTLICFL 261
            ..:|.|:  ..|:....|......||...|..|        .::||.:         |::.||.|
Human   169 VVLPFAV--FARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAI---------PVSTICVL 222

  Fly   262 YMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSV 326
            |..:|.||..........|..| .|:|||.:||.::....:||.|.|:..|:........:.|.:
Human   223 YTTLLCRLHAMRLDSHAKALER-AKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286

  Fly   327 IIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWC 364
            .|......::|.|||:||.|||||..:||:..|:::.|
Human   287 AISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITC 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	49/166 (30%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	77/265 (29%)
NPBWR1	NP_005276.2	7tmA_NPBWR	47..318	CDD:320215	87/283 (31%)
		TM helix 2	72..98	CDD:320215	12/26 (46%)
		TM helix 3	109..139	CDD:320215	10/29 (34%)
		TM helix 4	153..175	CDD:320215	3/21 (14%)
		TM helix 5	200..229	CDD:320215	8/37 (22%)
		TM helix 6	244..274	CDD:320215	12/30 (40%)
		TM helix 7	286..311	CDD:320215	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010