DRSC/TRiP Functional Genomics Resources

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Protein Alignment AstA-R1 and CMKLR2

DIOPT Version :9

Sequence 1:NP_524700.1 Gene:AstA-R1 / 44126 FlyBaseID:FBgn0266429 Length:394 Species:Drosophila melanogaster
Sequence 2:NP_001091669.1 Gene:CMKLR2 / 2825 HGNCID:4463 Length:355 Species:Homo sapiens


Alignment Length:334 Identity:85/334 - (25%)
Similarity:154/334 - (46%) Gaps:40/334 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 NYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQM 105
            ||::..::.         |:|.|.|......:|..:..|.:.:....|:.||.:||. ....:..
Human    14 NYSYDLDYY---------SLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIW-FTGFKWK 68

  Fly   106 RSTTNLLIINLAVSDILFVIFC---VPFTATDYVLPEWPFGNVW-CKFVQYMIVVTCHCSVYTLV 166
            ::.|.|..:|||::|.:|::|.   :.:.|.::   .|||| :| ||...:...:....||:.|.
Human    69 KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNF---HWPFG-IWLCKANSFTAQLNMFASVFFLT 129

  Fly   167 LMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACV-- 229
            ::|.|.::.::|||.|...||.:|:.:.|:..|:.......|.........:..|    |.|.  
Human   130 VISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH----TLCYNN 190

  Fly   230 FSTEEEIWSLVGFQVSF---FLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTR 291
            |...:...:|:...|..   |:..|:.||..:...|:.::.::.|         .|.....|...
Human   191 FQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK---------RSILISSRHFW 246

  Fly   292 MVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQI---ISHVVAYTNSCINPILYAFLSDN 353
            .::|||:||.:||.|.|:..:.: |.::..|:...::|.   :|..:|:.|||:|||||..:|..
Human   247 TILVVVVAFVVCWTPYHLFSIWE-LTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKK 310

  Fly   354 FRKAFRKVV 362
            |:..||..|
Human   311 FQARFRSSV 319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AstA-R1NP_524700.1 7tm_4 83..>240 CDD:304433 40/162 (25%)
7tm_1 91..347 CDD:278431 69/267 (26%)
CMKLR2NP_001091669.1 7tmA_GPR1 39..315 CDD:320247 75/294 (26%)
TM helix 1 41..65 CDD:320247 6/24 (25%)
TM helix 2 73..94 CDD:320247 7/20 (35%)
TM helix 3 111..133 CDD:320247 4/21 (19%)
TM helix 4 156..172 CDD:320247 2/15 (13%)
TM helix 5 204..227 CDD:320247 5/22 (23%)
TM helix 6 245..267 CDD:320247 9/21 (43%)
TM helix 7 283..308 CDD:320247 11/24 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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