Protein Alignment AstA-R1 and Cmklr2

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_666362.1
• Gene: Cmklr2 / 241070
• MGIID: 2385324
• Length: 353
• Species: Mus musculus
• Alignment Length: 374
• Identity: 88/374 - (23%)
• Similarity: 167/374 - (44%)
• Gaps: 57/374 - (15%)

  Fly    40 NNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQ 104
            :||::..::.         |.|.|.|......:|..|....:.:....|:.||.:||. ::..:.
Mouse    13 DNYSYALDYY---------SQESDPEEKVYLGLVHWISLFLYALAFVLGIPGNAIVIW-LMGFKW 67

  Fly   105 MRSTTNLLIINLAVSDILFVIFC---VPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLV 166
            .::.|.|..:|||::|.:||:|.   :.:.|..:   .||||...||...::..:....||:.|.
Mouse    68 KKTVTTLWFLNLAIADFIFVLFLPLYISYVALSF---HWPFGLWLCKVNSFIAQLNMFSSVFFLT 129

  Fly   167 LMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFS 231
            ::|.||::.::||..|...||.:::.:.::..|:.......|............|    ..|..:
Mouse   130 VISLDRYIHLLHPGLSHRHRTLKSSLVVVILVWLLASLLGGPTLYFRDTMEVNNH----IICYNN 190

  Fly   232 TEEEIWSLVGFQVSF---FLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTR-- 291
            .:|...:|:...|..   ||..|:.||..:...|:.::.::             :|....::|
Mouse   191 FQEHELTLMRHHVLTWVKFLFGYLFPLLTMSSCYLCLIFKM-------------KKRNILISRKH 242

  Fly   292 --MVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQ---IISHVVAYTNSCINPILYAFLS 351
              |::.||:||.:||.|.|:..:.: |:::..|....::|   .:|..:|:.|||:|||||..:|
Mouse   243 LWMILSVVIAFLVCWTPYHLFSIWE-LSIHHNSSFQNVLQGGIPLSTGLAFLNSCLNPILYVLIS 306

  Fly   352 DNFRKAFR--------KVVWCGSPPPLMTNQQVTKTTRTATGNGTSNIE 392
            ..|:..||        :.:|..|     .:..|::..|:|.....|.:|
Mouse   307 KTFQARFRASVAEVLKRSLWEAS-----CSGTVSEQLRSAETKSLSLLE 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	72/295 (24%)
		TM helix 1	76..102	CDD:320224	6/25 (24%)
		TM helix 2	109..135	CDD:320224	10/28 (36%)
		TM helix 3	147..177	CDD:320224	8/29 (28%)
		TM helix 4	189..209	CDD:320224	1/19 (5%)
		TM helix 5	239..268	CDD:320224	8/31 (26%)
		TM helix 6	284..314	CDD:320224	11/33 (33%)
		TM helix 7	326..351	CDD:320224	11/27 (41%)
Cmklr2	NP_666362.1	7tmA_GPR1	39..313	CDD:320247	72/295 (24%)
		TM helix 1	40..66	CDD:320247	6/26 (23%)
		TM helix 2	72..97	CDD:320247	9/24 (38%)
		TM helix 3	110..140	CDD:320247	8/29 (28%)
		TM helix 4	152..172	CDD:320247	1/19 (5%)
		TM helix 5	201..226	CDD:320247	7/24 (29%)
		TM helix 6	237..267	CDD:320247	10/29 (34%)
		TM helix 7	281..306	CDD:320247	11/24 (46%)