DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Gpr1

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001343974.1	Gene:	Gpr1 / 241070	MGIID:	2385324	Length:	353	Species:	Mus musculus

Alignment Length:	374	Identity:	88/374 - (23%)
Similarity:	167/374 - (44%)	Gaps:	57/374 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQ 104
            :||::..::.         |.|.|.|......:|..|....:.:....|:.||.:||. ::..:.
Mouse    13 DNYSYALDYY---------SQESDPEEKVYLGLVHWISLFLYALAFVLGIPGNAIVIW-LMGFKW 67

  Fly   105 MRSTTNLLIINLAVSDILFVIFC---VPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLV 166
            .::.|.|..:|||::|.:||:|.   :.:.|..:   .||||...||...::..:....||:.|.
Mouse    68 KKTVTTLWFLNLAIADFIFVLFLPLYISYVALSF---HWPFGLWLCKVNSFIAQLNMFSSVFFLT 129

  Fly   167 LMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFS 231
            ::|.||::.::||..|...||.:::.:.::..|:.......|............|    ..|..:
Mouse   130 VISLDRYIHLLHPGLSHRHRTLKSSLVVVILVWLLASLLGGPTLYFRDTMEVNNH----IICYNN 190

  Fly   232 TEEEIWSLVGFQVSF---FLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTR-- 291
            .:|...:|:...|..   ||..|:.||..:...|:.::.::             :|....::|
Mouse   191 FQEHELTLMRHHVLTWVKFLFGYLFPLLTMSSCYLCLIFKM-------------KKRNILISRKH 242

  Fly   292 --MVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQ---IISHVVAYTNSCINPILYAFLS 351
              |::.||:||.:||.|.|:..:.: |:::..|....::|   .:|..:|:.|||:|||||..:|
Mouse   243 LWMILSVVIAFLVCWTPYHLFSIWE-LSIHHNSSFQNVLQGGIPLSTGLAFLNSCLNPILYVLIS 306

  Fly   352 DNFRKAFR--------KVVWCGSPPPLMTNQQVTKTTRTATGNGTSNIE 392
            ..|:..||        :.:|..|     .:..|::..|:|.....|.:|
Mouse   307 KTFQARFRASVAEVLKRSLWEAS-----CSGTVSEQLRSAETKSLSLLE 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	37/159 (23%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	66/268 (25%)
Gpr1	NP_001343974.1	7tmA_GPR1	39..313	CDD:320247	72/295 (24%)
		TM helix 1	40..66	CDD:320247	6/26 (23%)
		TM helix 2	72..97	CDD:320247	9/24 (38%)
		TM helix 3	110..140	CDD:320247	8/29 (28%)
		TM helix 4	152..172	CDD:320247	1/19 (5%)
		TM helix 5	201..226	CDD:320247	7/24 (29%)
		TM helix 6	237..267	CDD:320247	10/29 (34%)
		TM helix 7	281..306	CDD:320247	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100