DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Sstr3

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001343890.1	Gene:	Sstr3 / 20607	MGIID:	98329	Length:	428	Species:	Mus musculus

Alignment Length:	377	Identity:	110/377 - (29%)
Similarity:	175/377 - (46%)	Gaps:	70/377 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TSEHTDHSDHNANDSMEYDA-----------ESVALERIVSTIVPVFFGIIGFAGLLGNGLVILV 98
            :||.|.....||:.:...|.           ..:|:..|:.::|   :.::...|||||.|||.|
Mouse     8 SSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLV---YLVVCVVGLLGNSLVIYV 69

  Fly    99 VVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVY 163
            |:.:....|.|::.|:|||::|.||:: .:||.|....|..||||::.|:.|..:..:....|::
Mouse    70 VLRHTSSPSVTSVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIF 133

  Fly   164 TLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTAC 228
            .|.:||.||:||||||..|...||...|.......|:......:||.:.           :|...
Mouse   134 CLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF-----------SGVPR 187

  Fly   229 VFSTEEEIW--SLVGFQVSFFLSS----YVAPLTLICFLYMGMLARL-------------WKSAP 274
            ..||....|  ....::.:|.:.:    :..||.:||..|:.::.::             |..||
Mouse   188 GMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAP 252

  Fly   275 GCKPSAESRKGKRRVTRMVVVVVLAFAICWLP------IHVILVLKALNLYGGSHLSVIIQIISH 333
            .|:   ..|:.:||||||||.||..|.:||:|      ::|:..|.....:.|.:..|:
Mouse   253 ACQ---RRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVV------ 308

  Fly   334 VVAYTNSCINPILYAFLSDNFRKAFRKVVW----------CGSPPPLMTNQQ 375
            .:.|.|||.|||||.|||..|::.||:::.          .||.||..|.::
Mouse   309 ALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	52/158 (33%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	85/280 (30%)
Sstr3	NP_001343890.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/11 (36%)
		7tm_GPCRs	46..333	CDD:391938	96/310 (31%)
		TM helix 1	48..72	CDD:341315	11/26 (42%)
		TM helix 2	81..102	CDD:341315	9/21 (43%)
		TM helix 3	118..140	CDD:341315	4/21 (19%)
		TM helix 4	163..179	CDD:341315	1/15 (7%)
		TM helix 5	205..228	CDD:341315	5/22 (23%)
		TM helix 6	262..287	CDD:341315	14/24 (58%)
		TM helix 7	301..326	CDD:341315	12/30 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..428		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010