DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Sstr1

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_033242.1	Gene:	Sstr1 / 20605	MGIID:	98327	Length:	391	Species:	Mus musculus

Alignment Length:	363	Identity:	104/363 - (28%)
Similarity:	186/363 - (51%)	Gaps:	51/363 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSWPKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVS------ 74
            ||.|..|.|:.|.|   :.|...|:              .|.|.||....:.:....:|
Mouse    11 SSSPSPSPGSCGEG---ACSRGPGS--------------GAADGMEEPGRNASQNGTLSEGQGSA 58

  Fly    75 TIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPE 139
            .::...:.::...||.||.:||.|::...:|::.||:.|:|||::|.|.:: .|||..|..:|..
Mouse    59 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLML-SVPFLVTSTLLRH 122

  Fly   140 WPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVT 204
            ||||.:.|:.|..:..|....|:|.|.::|.||::|||||:.:...|....|.:..:..|:..:.
Mouse   123 WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLL 187

  Fly   205 TAIPVALSHSVRIYQYHGNAGTACVFSTEE--EIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLA 267
            ..:|:.:......   :.:...||.....|  :.| ||||.:..||..::.|:..||..|:.::|
Mouse   188 VILPIVVFSRTAA---NSDGTVACNMLMPEPAQRW-LVGFVLYTFLMGFLLPVGAICLCYVLIIA 248

  Fly   268 RL--------WKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHL 324
            ::        |:         :.::.:|::|.||::||:.|.|||:|.:|:   :.:|::.....
Mouse   249 KMRMVALKAGWQ---------QRKRSERKITLMVMMVVMVFVICWMPFYVV---QLVNVFAEQDD 301

  Fly   325 SVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVV 362
            :.:.| :|.::.|.|||.|||||.||||||:::|::::
Mouse   302 ATVSQ-LSVILGYANSCANPILYGFLSDNFKRSFQRIL 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	47/158 (30%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	79/265 (30%)
Sstr1	NP_033242.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		13/55 (24%)
		7tmA_SSTR1	59..334	CDD:320636	89/292 (30%)
		TM helix 1	60..86	CDD:320636	7/25 (28%)
		TM helix 2	93..119	CDD:320636	12/26 (46%)
		TM helix 3	130..160	CDD:320636	10/29 (34%)
		TM helix 4	172..194	CDD:320636	3/21 (14%)
		TM helix 5	220..249	CDD:320636	10/28 (36%)
		TM helix 6	264..294	CDD:320636	12/32 (38%)
		TM helix 7	302..327	CDD:320636	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010