DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and npr-20

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_495888.3	Gene:	npr-20 / 188226	WormBaseID:	WBGene00011578	Length:	410	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	100/376 - (26%)
Similarity:	167/376 - (44%)	Gaps:	81/376 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ANDSMEYDAESVAL--ERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAV 118
            :|.:::.|..||:.  :..|...|.:.:.::....|.||.|.::|:.::..||:.||..:.|||:
Worm    10 SNATLDDDPCSVSFIDQPFVKIPVMIIYCLVFVVCLSGNFLTLIVMTSHPMMRTPTNFFLSNLAI 74

  Fly   119 SDILFVIFC-----VPFTATDYVLPEWPFGNVWCK-FVQYMIVVTCHCSVYTLVLMSFDRFLAVV 177
            :|:|..|||     :.....|:  ..||.|.|.|| ::....::.| .|...|||:|.::::||:
Worm    75 ADLLVAIFCILQNMIHIVGFDH--GNWPLGPVMCKLYLGLTNIMPC-TSAGILVLVSLEKYIAVL 136

  Fly   178 HPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEEIWSLVGF 242
            ||::.:.|.|..:..:|.|..|:..:....|..|  ..:.|.|   .|.:..|.....||:
Worm   137 HPLSGLKLLTPEHRWVATMIVWVISILVNFPYFL--YAQNYTY---LGVSACFRGSMPIWN---- 192

  Fly   243 QVSF-FLSSYVAPLTLICFLYMGMLARLWKS---------------------------APGCK-- 277
              || |:..|:.|||.:.|:|..:...||.|                           .||..
Worm   193 --SFSFIVWYLIPLTALVFIYSRISHLLWTSDSNRQSSRQSHESNGSLERGNGYANTAQPGSSWQ 255

  Fly   278 -----------------PSAESR----------KGKRRVTRMVVVVVLAFAICWLPIHVILVLKA 315
                             |..|.:          :|:|:|.|::|.||::||:...|.|..|:..:
Worm   256 MKNGRIVVYKQESLLNVPKREKKVKEPKRPKDTEGRRKVVRLLVAVVVSFALLTFPHHARLLYTS 320

  Fly   316 L--NLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWC 364
            .  .....|:.::|.|.:|::..:.:|.|||||||.||..||.|...|:.|
Worm   321 FQTGTICNSNWTMIFQPLSYIFLFISSAINPILYACLSKRFRNALSDVIHC 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	47/162 (29%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	83/320 (26%)
npr-20	NP_495888.3	7tmA_Trissin_R	32..365	CDD:320140	92/346 (27%)
		TM helix 1	33..57	CDD:320140	6/23 (26%)
		TM helix 2	66..88	CDD:320140	9/21 (43%)
		TM helix 3	107..129	CDD:320140	6/22 (27%)
		TM helix 4	152..168	CDD:320140	3/15 (20%)
		TM helix 5	189..212	CDD:320140	10/28 (36%)
		TM helix 6	292..317	CDD:320140	10/24 (42%)
		TM helix 7	333..358	CDD:320140	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850