DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and srx-64

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001317762.1	Gene:	srx-64 / 187095	WormBaseID:	WBGene00005955	Length:	302	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	53/245 - (21%)
Similarity:	89/245 - (36%)	Gaps:	72/245 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 MRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCH-CSVYTLVLM 168
            |.|||             |:||..|....|.  |.....:..|.||    ::.|: .||...:.:
Worm    53 MHSTT-------------FLIFFCPMVLLDE--PTLKAMSHHCGFV----LLLCYELSVMIHLAI 98

  Fly   169 SFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTE 233
            |.:||.||..|....::.::||.  .|:..::..||        .|:.||.|.    .:|.|..:
Worm    99 SLNRFCAVWAPYKYQNIFSDRNT--KILIGFVGTVT--------GSIAIYFYE----VSCHFYYD 149

  Fly   234 EEIWSL----------VGFQVSFFLSSYVAP-------LTLICFLYMG--MLARLWKSAPGCKPS 279
            |:|..|          :|:...|..::.:..       ||::....|.  :.:.:...|.....|
Worm   150 EKIHFLTFTNSEFCGYIGWYGDFLKNAVIVAIVVSIDILTVVKVKQMSKKISSSISDQAHSNLTS 214

  Fly   280 AESRKGKRRVTRMVV-------------------VVVLAFAICWLPIHVI 310
            .|.|..|:.||:..|                   :|..|.:..|:.:|.:
Worm   215 REIRFLKQTVTQGSVFMLELLTYFFVPRYFANRWIVFFATSFAWVAVHAV 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	36/145 (25%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	53/245 (22%)
srx-64	NP_001317762.1	TM helix 1	8..33	CDD:341315
		7TM_GPCR_Srx	14..273	CDD:370981	53/245 (22%)
		TM helix 2	40..66	CDD:341315	8/25 (32%)
		TM helix 3	77..107	CDD:341315	10/33 (30%)
		TM helix 4	120..138	CDD:341315	5/27 (19%)
		TM helix 5	163..188	CDD:341315	2/24 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910