Protein Alignment AstA-R1 and AGTR1

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_000676.1
• Gene: AGTR1 / 185
• HGNCID: 336
• Length: 359
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 88/345 - (25%)
• Similarity: 168/345 - (48%)
• Gaps: 32/345 - (9%)

  Fly    63 DAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFC 127
            |.........:..::|..:.||...|:.||.||::|:....::::..::.::|||::|:.|:: .
Human    17 DCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLL-T 80

  Fly   128 VP----FTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTE 188
            :|    :||.:|   .|||||..||.....:....:.||:.|..:|.||:||:|||:.|...||.
Human    81 LPLWAVYTAMEY---RWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTM 142

  Fly   189 RNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAG-TACVFSTEEEIWSL-VGFQVSFFLSSY 251
            ..|.:..:..|:.....::|..:..:|...:   |.. |.|.|..|.:..:| :|..::..:..:
Human   143 LVAKVTCIIIWLLAGLASLPAIIHRNVFFIE---NTNITVCAFHYESQNSTLPIGLGLTKNILGF 204

  Fly   252 VAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRR---VTRMVVVVVLAFAICWLPIHVIL-- 311
            :.|..:|...|    ..:||:   .|.:.|.:|.|.|   :.::::.:||.|...|:| |.|.
Human   205 LFPFLIILTSY----TLIWKA---LKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIP-HQIFTF 261

  Fly   312 --VLKALNLYGGSHLSVIIQI---ISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWCGSPPPLM 371
              ||..|.:.....::.|:..   |:..:||.|:|:||:.|.||...|::.|.:::.. .||...
Human   262 LDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKY-IPPKAK 325

  Fly   372 TNQQVTKTTRTATGNGTSNI 391
            ::..::....|.:...:.|:
Human   326 SHSNLSTKMSTLSYRPSDNV 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	82/298 (28%)
		TM helix 1	76..102	CDD:320224	9/25 (36%)
		TM helix 2	109..135	CDD:320224	8/29 (28%)
		TM helix 3	147..177	CDD:320224	10/29 (34%)
		TM helix 4	189..209	CDD:320224	2/19 (11%)
		TM helix 5	239..268	CDD:320224	5/29 (17%)
		TM helix 6	284..314	CDD:320224	11/36 (31%)
		TM helix 7	326..351	CDD:320224	10/27 (37%)
AGTR1	NP_000676.1	7tmA_AT1R	29..313	CDD:320320	82/298 (28%)
		TM helix 1	30..56	CDD:320320	9/25 (36%)
		TM helix 2	63..88	CDD:320320	6/25 (24%)
		TM helix 3	101..131	CDD:320320	10/29 (34%)
		TM helix 4	144..165	CDD:320320	3/20 (15%)
		TM helix 5	192..221	CDD:320320	5/32 (16%)
		TM helix 6	233..263	CDD:320320	8/30 (27%)
		TM helix 7	281..306	CDD:320320	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..359		2/11 (18%)