DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Oprm1

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001291884.1	Gene:	Oprm1 / 18390	MGIID:	97441	Length:	474	Species:	Mus musculus

Alignment Length:	356	Identity:	114/356 - (32%)
Similarity:	184/356 - (51%)	Gaps:	12/356 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNG 93
            ||.:::|:..||.    |:....:......|.....::.:...:.:..:...:.|:...||.||.
Mouse    27 GSWLNLSHVDGNQ----SDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNF 87

  Fly    94 LVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTC 158
            ||:.|:|...:|::.||:.|.|||::|.| ....:||.:.:|::..|||||:.||.|..:.....
Mouse    88 LVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNM 151

  Fly   159 HCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGN 223
            ..|::||..||.||::||.|||.::..||.|||.:..:|.||......:||....:.:..|  |:
Mouse   152 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ--GS 214

  Fly   224 AGTACVFSTEEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRR 288
            ......||.....|..: .::..|:.:::.|:.:|...|..|:.|| ||......|.|..:..||
Mouse   215 IDCTLTFSHPTWYWENL-LKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRR 277

  Fly   289 VTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDN 353
            :||||:|||..|.:||.|||:.:::|||.....:....:.......:.|||||:||:|||||.:|
Mouse   278 ITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDEN 342

  Fly   354 FRKAFRKVVWCGSPPPLMTNQQVTKTTRTAT 384
            |::.||:  :| .|......||.:...|..|
Mouse   343 FKRCFRE--FC-IPTSSTIEQQNSARIRQNT 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	56/156 (36%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	89/255 (35%)
Oprm1	NP_001291884.1	7tm_4	77..>281	CDD:304433	70/208 (34%)
		7tm_1	85..336	CDD:278431	89/255 (35%)
		NPxxY, plays a role in stabilizing the activated conformation of the receptor. /evidence=ECO:0000269\|PubMed:26245379	332..336		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..383		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010