DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and srx-13

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001343636.1	Gene:	srx-13 / 183437	WormBaseID:	WBGene00005904	Length:	325	Species:	Caenorhabditis elegans

Alignment Length:	215	Identity:	49/215 - (22%)
Similarity:	93/215 - (43%)	Gaps:	32/215 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLII--NLAVSDILFVIFC 127
            :.:..|.::.....:||  :.|.||:.|.|.|.||:.|..::::...|.:  ::|.|.:|||.|
Worm    19 QEITREDVLLAAAIIFF--VAFFGLIFNLLGITVVMKNPILKNSFGTLCLSHSIANSGVLFVFF- 80

  Fly   128 VPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNAT 192
            :....|.|:..: ..|.:..|.:..:.::.....||:.:.:||:||.::..|..::.:.:.:|..
Worm    81 IWSAPTTYIQAQ-NVGGMLGKLLGQLNILCWDACVYSHLAISFNRFFSIAIPARAIFIFSRQNTL 144

  Fly   193 LAIMCAWITIVTTAIPVALSHSVRIYQYH-------------GNAGTAC--VFSTEEEIWSLVGF 242
            :.|...|.        :|..|....:.|.             ..|.|.|  |.||..:.::.|..
Worm   145 VIIGIVWF--------IAFCHIFPYFWYDKCFITYNPISWTWNFAPTECGHVISTYTDYYTSVAI 201

  Fly   243 QVSFFLSSYVAPLTLICFLY 262
               |...|.|..:|||..::
Worm   202 ---FIAMSSVDIMTLILLIF 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	39/173 (23%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	43/189 (23%)
srx-13	NP_001343636.1	TM helix 1	30..53	CDD:381740	10/24 (42%)
		7TM_GPCR_Srx	34..295	CDD:370981	48/200 (24%)
		TM helix 2	62..84	CDD:381740	7/22 (32%)
		TM helix 3	100..122	CDD:381740	3/21 (14%)
		TM helix 4	145..161	CDD:381740	4/23 (17%)
		TM helix 5	187..215	CDD:381740	9/30 (30%)
		TM helix 6	239..259	CDD:381740
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910