DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Sstr3

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_598206.1	Gene:	Sstr3 / 171044	RGDID:	620308	Length:	428	Species:	Rattus norvegicus

Alignment Length:	395	Identity:	113/395 - (28%)
Similarity:	178/395 - (45%)	Gaps:	90/395 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSWPKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVF 80
            |:||              :..|.||..|.||                 ...:|:..|:.::|
  Rat    21 SAWP--------------LDTSLGNASAGTS-----------------LAGLAVSGILISLV--- 51

  Fly    81 FGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNV 145
            :.::...|||||.|||.||:.:....|.|::.|:|||::|.||:: .:||.|....|..||||::
  Rat    52 YLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFML-GLPFLAAQNALSYWPFGSL 115

  Fly   146 WCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVA 210
            .|:.|..:..:....|::.|.:||.||:||||||..|...||...|.:.....|:......:||.
  Rat   116 MCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVV 180

  Fly   211 LSHSVRIYQYHGNAGTACVFSTEEEIW--SLVGFQVSFFLSS----YVAPLTLICFLYMGMLARL 269
            :.           :|.....||....|  ....::.:|.:.:    :..||.:||..|:.::.::
  Rat   181 VF-----------SGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKV 234

  Fly   270 -------------WKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLP------IHVILVLKA 315
                         |..||.|:   ..|:.:||||||||.||..|.:||:|      ::|:..|..
  Rat   235 RSTTRRVRAPSCQWVQAPACQ---RRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPE 296

  Fly   316 LNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVW----------CGSPPPL 370
            ...:.|.:..|:      .:.|.|||.|||||.|||..|::.||:::.          .||.||.
  Rat   297 EPAFFGLYFLVV------ALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPE 355

  Fly   371 MTNQQ 375
            .|.::
  Rat   356 KTEEE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	52/158 (33%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	85/280 (30%)
Sstr3	NP_598206.1	7tm_GPCRs	46..333	CDD:421689	96/310 (31%)
		TM helix 1	47..73	CDD:410628	11/28 (39%)
		TM helix 2	80..106	CDD:410628	11/26 (42%)
		TM helix 3	117..147	CDD:410628	10/29 (34%)
		TM helix 4	159..181	CDD:410628	4/21 (19%)
		TM helix 5	204..233	CDD:410628	6/28 (21%)
		TM helix 6	259..289	CDD:410628	14/29 (48%)
		TM helix 7	301..326	CDD:410628	12/30 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..428		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010