DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Ptgdr2

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_034092.1	Gene:	Ptgdr2 / 14764	MGIID:	1330275	Length:	382	Species:	Mus musculus

Alignment Length:	339	Identity:	90/339 - (26%)
Similarity:	146/339 - (43%)	Gaps:	67/339 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 HNANDSMEY-DAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRST-TNLLIINL 116
            :::|.|:.| |..||.|.           |:....||:.|||::.||  ..:||.| ....:::|
Mouse    21 NHSNSSLRYIDHVSVLLH-----------GLASLLGLVENGLILFVV--GCRMRQTVVTTWVLHL 72

  Fly   117 AVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVT 181
            |:||:|.......||....|...|..|..:||....:..:....|.:.|..:|.||.|.||.||.
Mouse    73 ALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVW 137

  Fly   182 SMSLRTERNATLAIMCAWITIVTTAIPVALSHSV------RIYQYHG----NAG----TACVFST 232
            :.:.||...|....:..|...|...||..:....      ||..|:.    |.|    |.|.:..
Mouse   138 AQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQ 202

  Fly   233 EEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRV---TRMVV 294
            :       ...||.||.:::.||.:|...::.:..||            ..:|::|.   .|:|.
Mouse   203 K-------ALAVSKFLLAFMVPLAIIASSHVAVSLRL------------HHRGRQRTGRFVRLVA 248

  Fly   295 VVVLAFAICWLPIHVILVLKALNLYGGSH-LSVIIQIISH------VVAYTNSCINPILYAFLSD 352
            .:|:||.:||.|.|:..:|:|     .:| ::.:.|:.|.      .:|:.||.:||:||.|...
Mouse   249 AIVVAFVLCWGPYHIFSLLEA-----RAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCP 308

  Fly   353 N----FRKAFRKVV 362
            :    .|::.|.|:
Mouse   309 DMLYKLRRSLRAVL 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	46/171 (27%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	74/280 (26%)
Ptgdr2	NP_034092.1	7tm_GPCRs	32..314	CDD:391938	83/318 (26%)
		TM helix 1	34..58	CDD:341315	11/36 (31%)
		TM helix 2	66..87	CDD:341315	5/20 (25%)
		TM helix 3	104..126	CDD:341315	3/21 (14%)
		TM helix 4	149..165	CDD:341315	3/15 (20%)
		TM helix 5	203..226	CDD:341315	7/29 (24%)
		TM helix 6	241..266	CDD:341315	9/24 (38%)
		TM helix 7	282..307	CDD:341315	9/24 (38%)
		Involved in the recycling of CRTH2. /evidence=ECO:0000250	329..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100