DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Ackr2

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_511176.2	Gene:	Ackr2 / 140473	RGDID:	620323	Length:	382	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	102/373 - (27%)
Similarity:	173/373 - (46%)	Gaps:	67/373 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LATLISSWPKASWGATGNGSIISVSNSSGNNYAFTSEHT------DHSDHNANDSMEYDAESVAL 69
            :.|:.|..|.|:.|.....||.        :|.:..:.|      |              |.::.
  Rat     1 MPTIASPLPLATTGPENGSSIY--------DYDYLDDVTVLVCSKD--------------EVLSF 43

  Fly    70 ERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQ--QMRSTTNLLIINLAVSDILFVIFCVPFTA 132
            .|:   .:||.:.:|...||.|| |::|||:.:.  |.|....|.::|||||::|||: .:||.|
  Rat    44 GRV---FLPVVYSLIFVLGLAGN-LLLLVVLLHSVPQRRRMIELYLLNLAVSNLLFVV-TMPFWA 103

  Fly   133 TDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMC 197
            .. |...|.||:..||.|..:..:..:|.::.:..||.|::|.:||.......:|.....|.|:.
  Rat   104 IS-VAWHWVFGSFLCKVVSTLYSINFYCGIFFITCMSLDKYLEIVHAQPLHRPKTRFRNLLLIVM 167

  Fly   198 AWITIVTTAIPVALSHSVRIYQ-----YHGNAGTACVFSTEEEIWSL-VGFQVSFFLSSYVAPLT 256
            .|||.:..::|..:  .|:::|     :|..|.    |.....||.| :.||::  |..::.||.
  Rat   168 VWITALAVSVPEMV--FVKVHQTLDGVWHCYAD----FGGHATIWKLYLRFQMN--LLGFLFPLL 224

  Fly   257 LICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKA---LNL 318
            .:.|.|         |..||........|:.|..|....:|:.|.:.|.|.::.|.|.:   |::
  Rat   225 AMIFFY---------SRIGCVLVRLRPPGQGRALRTAAALVVVFFLLWFPYNLTLFLHSLLDLHV 280

  Fly   319 YGG---SH-LSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVV 362
            :|.   || |..::| ::..:|:::.|..|:||||.|.:||:..:.|:
  Rat   281 FGNCEISHRLDYMLQ-VTESLAFSHCCFTPVLYAFSSHSFRQYLKAVL 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	52/164 (32%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	77/270 (29%)
Ackr2	NP_511176.2	7tmA_ACKR2_D6	46..323	CDD:320316	89/300 (30%)
		TM helix 1	48..72	CDD:320316	11/24 (46%)
		TM helix 2	82..103	CDD:320316	11/21 (52%)
		TM helix 3	118..140	CDD:320316	4/21 (19%)
		TM helix 4	163..179	CDD:320316	5/15 (33%)
		TM helix 5	208..231	CDD:320316	8/33 (24%)
		TM helix 6	249..271	CDD:320316	5/21 (24%)
		TM helix 7	291..316	CDD:320316	8/25 (32%)
		C-terminal cytoplasmic tail. /evidence=ECO:0000250	327..382		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000