DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Ackr3

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001258536.1	Gene:	Ackr3 / 12778	MGIID:	109562	Length:	362	Species:	Mus musculus

Alignment Length:	352	Identity:	85/352 - (24%)
Similarity:	163/352 - (46%)	Gaps:	62/352 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NYAFTSEHTD-HSDHNANDSMEYDA--------ESVALERIVSTIVPVFFGIIGFAGLLGNGLVI 96
            :||....::| :...|::|.:..|.        ::|.|..:  :.:.:|..:|   |::.|.:|:
Mouse     7 DYAEPGNYSDINWPCNSSDCIVVDTVQCPTMPNKNVLLYTL--SFIYIFIFVI---GMIANSVVV 66

  Fly    97 LVVVANQQMRST---TNLLIINLAVSDILFVIFCVPFTATDYVL-PEWPFGNVWCKFVQYMIVVT 157
            .|   |.|.::|   |:..|:|||::| |:|:..:|......|. .:||.|.:.||....:..:.
Mouse    67 WV---NIQAKTTGYDTHCYILNLAIAD-LWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSIN 127

  Fly   158 CHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHG 222
            ...|::.|..||.||:|::.:...:.|.:.:....:..:..|:.....::|.  ::.::......
Mouse   128 LFGSIFFLACMSVDRYLSITYFTGTSSYKKKMVRRVVCILVWLLAFFVSLPD--TYYLKTVTSAS 190

  Fly   223 NAGTAC-VFSTEEEI--WSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRK 284
            |..|.| .|..|..|  | |:|.::...:..:..|.|:|...|. :|||. .||.|.:....|||
Mouse   191 NNETYCRSFYPEHSIKEW-LIGMELVSVILGFAVPFTIIAIFYF-LLARA-MSASGDQEKHSSRK 252

  Fly   285 GKRRVTRMVVVVVLAFAICWLPIHVILVLKALN--------------LYGGSHLSVIIQIISHVV 335
                   ::...|:.|.:||||.|.:::|...:              |:...|::..:.::
Mouse   253 -------IIFSYVVVFLVCWLPYHFVVLLDIFSILHYIPFTCQLENVLFTALHVTQCLSLV---- 306

  Fly   336 AYTNSCINPILYAFLSDNFR----KAF 358
               :.|:||:||:|::.|:|    |||
Mouse   307 ---HCCVNPVLYSFINRNYRYELMKAF 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	40/163 (25%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	66/276 (24%)
Ackr3	NP_001258536.1	7tmA_ACKR3_CXCR7	45..326	CDD:320118	74/308 (24%)
		TM helix 1	47..71	CDD:320118	7/31 (23%)
		TM helix 2	80..101	CDD:320118	8/21 (38%)
		TM helix 3	118..140	CDD:320118	4/21 (19%)
		TM helix 4	163..179	CDD:320118	1/15 (7%)
		TM helix 5	210..233	CDD:320118	4/22 (18%)
		TM helix 6	251..273	CDD:320118	9/28 (32%)
		TM helix 7	294..319	CDD:320118	7/31 (23%)
		C-terminal cytoplasmic tail. /evidence=ECO:0000250	324..362		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837215
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930