DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Cxcr2

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_034039.1	Gene:	Cxcr2 / 12765	MGIID:	105303	Length:	359	Species:	Mus musculus

Alignment Length:	363	Identity:	97/363 - (26%)
Similarity:	162/363 - (44%)	Gaps:	78/363 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDIL 122
            |::...:|::   .|.|..|.|.:.::....|:||.||:||::.|:...|.|::.::|||::|:.
Mouse    34 DAVPCHSENL---EINSYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLF 95

  Fly   123 FVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRT 187
            |.: .:|..|...| ..|.||:..||...|:..||.:.||..|..:|.||:||:|| .||..::.
Mouse    96 FAL-TLPVWAASKV-NGWTFGSTLCKIFSYVKEVTFYSSVLLLACISMDRYLAIVH-ATSTLIQK 157

  Fly   188 ERNATLAIMCAWITIVTTAIPV-ALSHSVRI-------YQYHGNAGTACVFSTEEEIWSLVGFQV 244
            ........:..|:..|..|:|: .|.:.|::       |:..|| .|:.:......:....||.|
Mouse   158 RHLVKFVCIAMWLLSVILALPILILRNPVKVNLSTLVCYEDVGN-NTSRLRVVLRILPQTFGFLV 221

  Fly   245 SFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHV 309
                     ||.::.|.|...|..|:|:..|         .|.|..|::..|||.|.:||||.::
Mouse   222 ---------PLLIMLFCYGFTLRTLFKAHMG---------QKHRAMRVIFAVVLVFLLCWLPYNL 268

  Fly   310 IL--------------------VLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNF 354
            :|                    :.||||             .:.::.:.:||:|||:|||:...|
Mouse   269 VLFTDTLMRTKLIKETCERRDDIDKALN-------------ATEILGFLHSCLNPIIYAFIGQKF 320

  Fly   355 RKAFRKVVWC------------GSPPPLMTNQQVTKTT 380
            |....|::..            |.|..:.::...|.||
Mouse   321 RHGLLKIMATYGLVSKEFLAKEGRPSFVSSSSANTSTT 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	48/164 (29%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	79/283 (28%)
Cxcr2	NP_034039.1	7tmA_CXCR1_2	48..324	CDD:341333	87/310 (28%)
		TM helix 1	48..75	CDD:341333	9/26 (35%)
		TM helix 2	82..107	CDD:341333	8/25 (32%)
		TM helix 3	118..148	CDD:341333	13/29 (45%)
		TM helix 4	159..181	CDD:341333	4/21 (19%)
		TM helix 5	207..235	CDD:341333	7/36 (19%)
		TM helix 6	243..273	CDD:341333	13/38 (34%)
		TM helix 7	292..317	CDD:341333	12/37 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000