DRSC/TRiP Functional Genomics Resources

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Protein Alignment AstA-R1 and ACKR2

DIOPT Version :9

Sequence 1:NP_524700.1 Gene:AstA-R1 / 44126 FlyBaseID:FBgn0266429 Length:394 Species:Drosophila melanogaster
Sequence 2:NP_001287.2 Gene:ACKR2 / 1238 HGNCID:1565 Length:384 Species:Homo sapiens


Alignment Length:368 Identity:99/368 - (26%)
Similarity:164/368 - (44%) Gaps:58/368 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 ATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVS---TIVPVFFGIIGF 86
            ||.:...::..::...|.:|  .:.|:.|..|......||       :||   ..:|||:.:|..
Human     3 ATASPQPLATEDADSENSSF--YYYDYLDEVAFMLCRKDA-------VVSFGKVFLPVFYSLIFV 58

  Fly    87 AGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQ 151
            .||.||.|:::|::.....|....:.::|||:|::||:: .:||.... |...|.||:..||.|.
Human    59 LGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLV-TLPFWGIS-VAWHWVFGSFLCKMVS 121

  Fly   152 YMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVR 216
            .:..:..:..::.:..||.|::|.:||......|||...:.|.....|...:..:||     .:.
Human   122 TLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIP-----DMV 181

  Fly   217 IYQYHGNA----GTACVFSTEEEIWSL-VGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGC 276
            ..|.|.|.    .....|.....||.| :.||.:  |..::.||..:.|.|         |..||
Human   182 FVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQN--LLGFLLPLLAMIFFY---------SRIGC 235

  Fly   277 -----KPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKA---LNLYG----GSHLSVIIQ 329
                 :|:     |:.|..::...:|:||.:.|.|.::.|.|..   |.::|    ..||...:|
Human   236 VLVRLRPA-----GQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQ 295

  Fly   330 IISHVVAYTNSCINPILYAFLSDNFR---KAFRKVV--WCGSP 367
             ::..:|:.:.|.:||||||.|..||   |||...|  |..:|
Human   296 -VTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAP 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AstA-R1NP_524700.1 7tm_4 83..>240 CDD:304433 43/161 (27%)
7tm_1 91..347 CDD:278431 69/272 (25%)
ACKR2NP_001287.2 7tmA_ACKR2_D6 47..323 CDD:320316 82/299 (27%)
TM helix 1 47..74 CDD:320316 10/26 (38%)
TM helix 2 81..106 CDD:320316 8/26 (31%)
TM helix 3 117..147 CDD:320316 7/29 (24%)
TM helix 4 159..181 CDD:320316 4/26 (15%)
TM helix 5 207..236 CDD:320316 10/39 (26%)
TM helix 6 243..273 CDD:320316 8/34 (24%)
TM helix 7 291..316 CDD:320316 9/25 (36%)
C-terminal cytoplasmic tail 327..384 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..384
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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