Protein Alignment AstA-R1 and CCR8

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_005192.1
• Gene: CCR8 / 1237
• HGNCID: 1609
• Length: 355
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 98/331 - (29%)
• Similarity: 179/331 - (54%)
• Gaps: 28/331 - (8%)

  Fly    41 NYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQM 105
            :|......|..:|:...|......::..::.....::.||:.::....||||.|||||:|..:::
Human     2 DYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKL 66

  Fly   106 RSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSF 170
            ||.|::.::|||:||:||| |..|| .|.|:|.:|.||.|.||.|.....:..:.|::.:.|||.
Human    67 RSITDVYLLNLALSDLLFV-FSFPF-QTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSV 129

  Fly   171 DRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFS--TE 233
            ||:|||||.|.::.:||.|..|...:..|:|.:...||:.:     .||.....|....:|  .:
Human   130 DRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLV-----FYQVASEDGVLQCYSFYNQ 189

  Fly   234 EEI-WSL-VGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVV 296
            :.: |.: ..|:::  :...:.|.|:..|.|:.:|.:|.:    |:     ...|.:..|:|::|
Human   190 QTLKWKIFTNFKMN--ILGLLIPFTIFMFCYIKILHQLKR----CQ-----NHNKTKAIRLVLIV 243

  Fly   297 VLAFAICWLPIHVILVLKAL---NLYGGSHLSVIIQIISHV---VAYTNSCINPILYAFLSDNFR 355
            |:|..:.|:|.:|:|.|.:|   ::..|..:|..:...:||   :::|:.|:||::|||:.:.|:
Human   244 VIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFK 308

  Fly   356 KAFRKV 361
            |...::
Human   309 KHLSEI 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	94/292 (32%)
		TM helix 1	76..102	CDD:320224	12/25 (48%)
		TM helix 2	109..135	CDD:320224	13/25 (52%)
		TM helix 3	147..177	CDD:320224	11/29 (38%)
		TM helix 4	189..209	CDD:320224	5/19 (26%)
		TM helix 5	239..268	CDD:320224	6/29 (21%)
		TM helix 6	284..314	CDD:320224	10/29 (34%)
		TM helix 7	326..351	CDD:320224	9/27 (33%)
CCR8	NP_005192.1	7tmA_CCR8	36..311	CDD:320315	94/292 (32%)
		TM helix 1	36..63	CDD:320315	12/26 (46%)
		TM helix 2	70..95	CDD:320315	13/26 (50%)
		TM helix 3	106..136	CDD:320315	11/29 (38%)
		TM helix 4	148..170	CDD:320315	6/21 (29%)
		TM helix 5	195..224	CDD:320315	6/30 (20%)
		TM helix 6	231..261	CDD:320315	10/29 (34%)
		TM helix 7	279..304	CDD:320315	9/24 (38%)