Protein Alignment AstA-R1 and CCR1

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_001286.1
• Gene: CCR1 / 1230
• HGNCID: 1602
• Length: 355
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 90/361 - (24%)
• Similarity: 182/361 - (50%)
• Gaps: 48/361 - (13%)

  Fly    53 DHNANDSMEY-DA---ESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLI 113
            |::.....:| ||   :.|......:.::|..:.::...||:||.||:||:|..:::::.|::.:
Human     9 DYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYL 73

  Fly   114 INLAVSDILFVIFCVPFTATDYVL-PEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVV 177
            :|||:||:|| :|.:||. .||.| .:|.||:..||.:........:..::.::|::.||:||:|
Human    74 LNLAISDLLF-LFTLPFW-IDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIV 136

  Fly   178 HPVTSMSLRTERNATLAIMCAWITIVTTAIP-VALSHSVRIYQYHGNAGTACVFSTEEEI--WSL 239
            |.|.::..||.....:..:..|...:..::| :..|.:...:.:|    |..:....|.:  |.|
Human   137 HAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHH----TCSLHFPHESLREWKL 197

  Fly   240 VGFQ-VSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAIC 303
              || :...|...|.||.::...|.|::..|.:     :|:.:    |.:..|::.|:::.|.:.
Human   198 --FQALKLNLFGLVLPLLVMIICYTGIIKILLR-----RPNEK----KSKAVRLIFVIMIIFFLF 251

  Fly   304 WLPIHVILVLKALNLY-------GGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRK- 360
            |.|.::.:::.....:       ...||.:.:| ::.|:|||:.|:||::|||:.:.|||..|:
Human   252 WTPYNLTILISVFQDFLFTHECEQSRHLDLAVQ-VTEVIAYTHCCVNPVIYAFVGERFRKYLRQL 315

  Fly   361 ---------VVWCGSPPPLMTNQQVTKTTRTATGNG 387
                     |.|.    |.::..::.:.:.|:...|
Human   316 FHRRVAVHLVKWL----PFLSVDRLERVSSTSPSTG 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	79/294 (27%)
		TM helix 1	76..102	CDD:320224	10/25 (40%)
		TM helix 2	109..135	CDD:320224	11/25 (44%)
		TM helix 3	147..177	CDD:320224	7/29 (24%)
		TM helix 4	189..209	CDD:320224	2/20 (10%)
		TM helix 5	239..268	CDD:320224	9/29 (31%)
		TM helix 6	284..314	CDD:320224	6/29 (21%)
		TM helix 7	326..351	CDD:320224	11/24 (46%)
CCR1	NP_001286.1	7tmA_CCR1	35..312	CDD:320311	79/294 (27%)
		TM helix 1	35..62	CDD:320311	10/26 (38%)
		TM helix 2	69..94	CDD:320311	12/26 (46%)
		TM helix 3	106..136	CDD:320311	7/29 (24%)
		TM helix 4	148..170	CDD:320311	2/21 (10%)
		TM helix 5	196..225	CDD:320311	9/30 (30%)
		TM helix 6	232..262	CDD:320311	6/33 (18%)
		TM helix 7	280..305	CDD:320311	11/25 (44%)