DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and Kiss1r

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_444474.1	Gene:	Kiss1r / 114229	MGIID:	2148793	Length:	396	Species:	Mus musculus

Alignment Length:	372	Identity:	123/372 - (33%)
Similarity:	183/372 - (49%)	Gaps:	50/372 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LATLISSWPKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVST 75
            :||..:..|..:|.|.        ||:||         ......||:|    |..| |...:.:.
Mouse     1 MATEATLAPNVTWWAP--------SNASG---------CPGCGVNASD----DPGS-APRPLDAW 43

  Fly    76 IVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEW 140
            :||:||..:...||:||.|||.|:..::.|::.||..|.|||.:|:.|::.||||||..|.||.|
Mouse    44 LVPLFFATLMLLGLVGNSLVIYVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPAW 108

  Fly   141 PFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTT 205
            ..|:..||||.|:..|:...:..||..||.||:...|.|:.::..||.|.|....:..|:.....
Mouse   109 VLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAV 173

  Fly   206 AIPVALSHSV----RIYQYHGNAGTACVFSTEEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGML 266
            :.||...|.:    |.|     ...|......|..::|..     .|:.|:.||...|..|..||
Mouse   174 SAPVLALHRLSPGPRTY-----CSEAFPSRALERAFALYN-----LLALYLLPLLATCACYGAML 228

  Fly   267 ARLWKSAPGCKPSAESRKG----------KRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGG 321
            ..|.::|....|:..:.:|          :.:|:|:|..|||.||.||.||.:.|||:||...|.
Mouse   229 RHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGA 293

  Fly   322 ----SHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWC 364
                |:.:..::|.:|.::|:||.:||:|||||..:||:||.:|..|
Mouse   294 WHPRSYAAYAVKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPC 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	54/160 (34%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	91/273 (33%)
Kiss1r	NP_444474.1	7tmA_KiSS1R	43..334	CDD:320223	104/300 (35%)
		TM helix 1	44..70	CDD:320223	12/25 (48%)
		TM helix 2	77..103	CDD:320223	14/25 (56%)
		TM helix 3	115..145	CDD:320223	12/29 (41%)
		TM helix 4	157..177	CDD:320223	3/19 (16%)
		TM helix 5	201..230	CDD:320223	10/33 (30%)
		TM helix 6	256..286	CDD:320223	14/29 (48%)
		TM helix 7	302..327	CDD:320223	11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3950
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940