Protein Alignment AstA-R1 and NPFFR2

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_001138228.1
• Gene: NPFFR2 / 10886
• HGNCID: 4525
• Length: 423
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 107/358 - (29%)
• Similarity: 186/358 - (51%)
• Gaps: 50/358 - (13%)

  Fly    35 SNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERI--------VSTIVPVFFGIIGFAGLLG 91
            :|||.|         .|...|.||:..:....:.:..:        |:.|..:.:.:|.|..::|
Human    10 TNSSEN---------WHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMG 65

  Fly    92 NGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVV 156
            |.:|..:|:.|:.|.:.|||.|:|||:||:|..|||:|.|..|.::..|||||..||....:..:
Human    66 NTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGI 130

  Fly   157 TCHCSVYTLVLMSFDRFLAVVHPV-TSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQY 220
            :...||:|||.::.|||..||:|. ..::::|   |.:.||..|:..:|...|.|:...|:..:|
Human   131 SVAASVFTLVAIAVDRFQCVVYPFKPKLTIKT---AFVIIMIIWVLAITIMSPSAVMLHVQEEKY 192

  Fly   221 H-----GNAGTACVFSTEEE--------IWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKS 272
            :     ....|:.|:...|:        |::.|     .|.:.|:|||:||..:|..:...|:::
Human   193 YRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTV-----LFANIYLAPLSLIVIMYGRIGISLFRA 252

  Fly   273 A---PGCKPSAE----SRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVI--- 327
            |   .|.|...:    ||| |:::.:|:::|.|.|.:.|||:..:::|........:.|.:|
Human   253 AVPHTGRKNQEQWHVVSRK-KQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIY 316

  Fly   328 IQIISHVVAYTNSCINPILYAFLSDNFRKAFRK 360
            |...:|.:|:.||.:|||:|.|.::|||:.|::
Human   317 IYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQE 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	97/306 (32%)
		TM helix 1	76..102	CDD:320224	7/25 (28%)
		TM helix 2	109..135	CDD:320224	15/25 (60%)
		TM helix 3	147..177	CDD:320224	10/29 (34%)
		TM helix 4	189..209	CDD:320224	5/19 (26%)
		TM helix 5	239..268	CDD:320224	9/28 (32%)
		TM helix 6	284..314	CDD:320224	9/29 (31%)
		TM helix 7	326..351	CDD:320224	11/27 (41%)
NPFFR2	NP_001138228.1	7tmA_NPFFR2	49..347	CDD:320646	97/306 (32%)
		TM helix 1	50..76	CDD:320646	7/25 (28%)
		TM helix 2	83..109	CDD:320646	15/25 (60%)
		TM helix 3	121..151	CDD:320646	10/29 (34%)
		TM helix 4	162..183	CDD:320646	7/23 (30%)
		TM helix 5	219..248	CDD:320646	10/33 (30%)
		TM helix 6	270..300	CDD:320646	10/30 (33%)
		TM helix 7	315..340	CDD:320646	10/24 (42%)