DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and nmur2

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_002940961.1	Gene:	nmur2 / 100498226	XenbaseID:	XB-GENE-6046084	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	335	Identity:	96/335 - (28%)
Similarity:	161/335 - (48%)	Gaps:	40/335 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NDSMEYDAESVALERI-VSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSD 120
            |.:.||.|.....:|. :|..:.:.:..|...|::||.||.||::.:..||:.||..:.:|||||
Frog    26 NSTEEYLAYLCGPKRSRLSLPMTLVYATIFLIGVIGNTLVCLVILKHHNMRTPTNYYLFSLAVSD 90

  Fly   121 ILFVIFCVPFTATDYVLPEWP--FGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSM 183
            :|.::..:|....: :...:|  ||...|.|...:....|..|:.::..:|.:|::|::||..:.
Frog    91 LLVLLLGMPLEVYE-MWSNYPFLFGAWGCYFKTVLFETVCFASILSVTTVSVERYVAIIHPFQAK 154

  Fly   184 SLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNA-----GTACVFSTEEEIWSLVGFQ 243
            ...|...|...::..||..:..:||...:|.: :.||..|.     ...|.......|::.: .|
Frog   155 LKSTRSRALKILVTLWIFSILFSIPNTSTHGI-LLQYFPNGSLIPDSATCTVVQPLWIYNCI-IQ 217

  Fly   244 VSFFLSSYVAPLTLICFLY--MGMLARLWKSAPGCKPSAE-SRKGKRRVTRMVVVVVLAFAICWL 305
            |:..| .|:.|:.:|..||  ||:..|...|....|.|.. .|..::.:|:|:.|:|:.|.|||.
Frog   218 VTSLL-FYILPMGVISVLYCLMGIKLRGDHSLEADKMSVNVQRPSRKSITKMLFVLVMVFGICWA 281

  Fly   306 PIHV-------IL-----VLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAF 358
            |.||       :|     :..|.||   :|      ::|.|..|.:|.:||::|..||..||.||
Frog   282 PFHVDRLFFSFVLDWTEPLANAFNL---TH------VVSGVFFYLSSAVNPLIYNLLSRRFRSAF 337

  Fly   359 RKVVWCGSPP 368
            :.|:    ||
Frog   338 QNVL----PP 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	43/163 (26%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	78/277 (28%)
nmur2	XP_002940961.1	7tmA_NMU-R2	45..337	CDD:320479	85/304 (28%)
		TM helix 1	45..72	CDD:320479	8/26 (31%)
		TM helix 2	79..105	CDD:320479	9/26 (35%)
		TM helix 3	118..148	CDD:320479	7/29 (24%)
		TM helix 4	160..182	CDD:320479	5/21 (24%)
		TM helix 5	212..241	CDD:320479	10/30 (33%)
		TM helix 6	260..290	CDD:320479	11/29 (38%)
		TM helix 7	305..330	CDD:320479	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910