DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and oprm1

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_002933909.1	Gene:	oprm1 / 100487937	XenbaseID:	XB-GENE-1011391	Length:	388	Species:	Xenopus tropicalis

Alignment Length:	342	Identity:	117/342 - (34%)
Similarity:	185/342 - (54%)	Gaps:	26/342 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVS 119
            |.:::...|::|:    |::.|:...:.:|...||.||.||:.|:|...:|::.||:.|.|||::
Frog    54 NQSETFPEDSDSI----IIAIIITALYSMICVMGLFGNVLVMYVIVRYTKMKTATNIYIFNLALA 114

  Fly   120 DILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMS 184
            |.| ....:||.:.:|::..|||||:.||.|..:.......|::||..||.||::||.|||.::.
Frog   115 DAL-ATSTLPFQSVNYLMGTWPFGNIVCKIVISIDYYNMFTSIFTLTTMSVDRYIAVCHPVKALD 178

  Fly   185 LRTERNATLAIMCAWITIVTTAIPV---ALSHSVRIYQYHGNAGTACVFSTEEEIWSLVGFQVSF 246
            .||.|||.:..:|.||......:||   |.:.|.|     |:...|.:|......|..: .::..
Frog   179 FRTPRNAKIVNVCNWILSSAIGLPVMFMATTKSER-----GSTDCALLFPHPSWYWDNL-LKICV 237

  Fly   247 FLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVIL 311
            |:.:::.|:.:|...|..|:.|| ||......|.|..:..||:||||:|||..|.:||.|||:.:
Frog   238 FIFAFIMPVLIITVCYGMMILRL-KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV 301

  Fly   312 VLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWCGSPPPLMTNQQV 376
            ::|||.....|....:...:...:.|||||:||:|||||.:||::.||:  :|  .|...|.:|.
Frog   302 IIKALINIPPSLFQTVTWHVCIALGYTNSCLNPVLYAFLDENFKRCFRE--FC--IPTSSTIEQQ 362

  Fly   377 TKT-------TRTATGN 386
            ..|       .|.:|.|
Frog   363 NSTRMRHNTRDRASTAN 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	58/159 (36%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	92/258 (36%)
oprm1	XP_002933909.1	7tmA_Mu_opioid_R	73..348	CDD:320218	102/282 (36%)
		TM helix 1	73..97	CDD:320218	9/23 (39%)
		TM helix 2	104..130	CDD:320218	10/26 (38%)
		TM helix 3	141..171	CDD:320218	11/29 (38%)
		TM helix 4	183..205	CDD:320218	8/21 (38%)
		TM helix 5	230..259	CDD:320218	5/29 (17%)
		TM helix 6	274..304	CDD:320218	15/29 (52%)
		TM helix 7	316..341	CDD:320218	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100