DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and kiss1r

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001163985.1	Gene:	kiss1r / 100316929	XenbaseID:	XB-GENE-990075	Length:	366	Species:	Xenopus tropicalis

Alignment Length:	383	Identity:	129/383 - (33%)
Similarity:	195/383 - (50%)	Gaps:	43/383 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NGSIISVSNS--SGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLL 90
            |.|:.|.::|  .|..|..|         |.:|..:|.......:.:.:.:||:||.::...||.
Frog     3 NESLFSFNDSCLGGMVYLCT---------NMSDLEKYGDPPRPPQLVDAWLVPLFFAMLMLVGLT 58

  Fly    91 GNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIV 155
            ||.|||.|:..::|||:.||..|.|||.:||:|::.||||||..|.||.|.||...||||.|:..
Frog    59 GNSLVIYVISKHKQMRTVTNFYIANLAATDIIFLVSCVPFTAALYPLPGWIFGEFMCKFVNYIQQ 123

  Fly   156 VTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQY 220
            |:...:..||..||.||:...|:|:.|:..||.|.|....:..||.....:|||.:.:.: |..|
Frog   124 VSVQATCVTLTAMSVDRWYVTVYPLQSLRQRTPRVAAAVSVGIWIGSFIVSIPVPIYNQL-IEGY 187

  Fly   221 HGNAGTACVFSTEEEIWSLVGFQVSF----FLSSYVAPLTLICFLYMGMLARLWKSAPGCKP--- 278
            .......|     .|.:..|..:.:|    ||..|:.||..||..|..|:.::.:  |..:|
Frog   188 WFGPQIYC-----SESFPSVSHEKAFILYNFLVVYLLPLITICICYSAMVYQMGR--PSVEPVDN 245

  Fly   279 -------SAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALN-LYGGSHLSVIIQIISHVV 335
                   :..|...:.:::|||.|:||.|.|||.||.:.::.:|.: .:...:.:..::|.::.:
Frog   246 SYQVQLLAERSELMRTKISRMVAVIVLLFTICWGPIQLYILFQAFSPSFKRDYYTYKVKIWANCM 310

  Fly   336 AYTNSCINPILYAFLSDNFRKAFRKVVWCGSPPPLMTNQQVTKTTRTATGNGTSNIEM 393
            :||||.||||:|||:..||||||.||.      |.:..|:|..   |...|..:|.||
Frog   311 SYTNSSINPIVYAFMGANFRKAFNKVF------PFLFKQRVGS---TGVANANANTEM 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	60/156 (38%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	94/270 (35%)
kiss1r	NP_001163985.1	7tmA_KiSS1R	43..333	CDD:320223	107/297 (36%)
		TM helix 1	44..70	CDD:320223	12/25 (48%)
		TM helix 2	77..103	CDD:320223	15/25 (60%)
		TM helix 3	115..145	CDD:320223	12/29 (41%)
		TM helix 4	157..177	CDD:320223	5/19 (26%)
		TM helix 5	205..234	CDD:320223	10/28 (36%)
		TM helix 6	258..288	CDD:320223	12/29 (41%)
		TM helix 7	301..326	CDD:320223	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14084
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3950
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950