DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgm and ACSL6

DIOPT Version :9

Sequence 1:	NP_001285923.1	Gene:	bgm / 44117	FlyBaseID:	FBgn0027348	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001009185.1	Gene:	ACSL6 / 23305	HGNCID:	16496	Length:	722	Species:	Homo sapiens

Alignment Length:	706	Identity:	185/706 - (26%)
Similarity:	316/706 - (44%)	Gaps:	112/706 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AYRTTNRQDA--------VKIRMAKDGIGAEEPI--SVPGLL--------------KRTVNNYGD 61
            ||..|:|..|        ::....:|..||...:  |.|.||              :|.::..|:
Human    66 AYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGN 130

  Fly    62 YPALRTKNGKNGYHTVTYKQYEQKVHQVAKAFIKLGLEEHHS-------VGVLAFNCAEWFYSAM 119
            .|.|..:..|..|..::|::...:..     |:..||.:|:.       :||.|.|..||....:
Human   131 GPCLGFRKPKQPYQWLSYQEVADRAE-----FLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVEL 190

  Fly   120 GAIHARGIIAGIYTTNSADAVQHVLESSHAQIVVVDDAKQMDKI--HAIRDKLPKLKAAIQIQEP 182
            .......::..:|.|....|:::::.::....|:||..::...:  |..|.:.|.||..| :.:|
Human   191 ACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLII-LMDP 254

  Fly   183 YSPYLKKEDGYYRWSEIESMNVSDVEDQYMTRLENVAI------NECCCLVYTSGTVGMPKGVML 241
            :...| ||.|......|:||..  |||   ...||...      ::...:.:||||.|.|||.||
Human   255 FEEAL-KERGQKCGVVIKSMQA--VED---CGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAML 313

  Fly   242 SHDNITFDVRGIVKAMDRVVVGAES--IVSYLPLSHVAAQTV-DIYTCAFVAGCIWFADKDALKG 303
            :|.|:..|..|.:|..::|:...:.  ::|:|||:|:..:.: .:..|.  .|.:.|...|
Human   314 THGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCH--GGRVGFFQGD---- 372

  Fly   304 TLVKSLQDAR----PTRFMGVPRVYEKFQERMVAVASSSGSLKKMLASWA---KGITLKHYMVSQ 361
              ::.|.|..    ||.|..|||:..:..:::.:.|::  .||:.|..:|   |...::
Human   373 --IRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANT--PLKRWLLEFAAKRKQAEVR------ 427

  Fly   362 GKSSGGFRY-KIAKSLIMSKVKQALGFDRVLTLASAAAPMSPETKKYFL--SLDLKIVDAFGMSE 423
               ||..|. .|...|..:|::.:|| ..|..:.:.|||.|| |...||  :|..::.:.:|.:|
Human   428 ---SGIIRNDSIWDELFFNKIQASLG-GCVRMIVTGAAPASP-TVLGFLRAALGCQVYEGYGQTE 487

  Fly   424 -TAGCHTICLPDSVGLNTIGKTLPGCESKFINKD------ANGHGELCIRGRHVFMGYIDNKEKT 481
             |||| |...|.......:|..||....|.::.:      ..|.||:|:||.:||.||:.:.::|
Human   488 CTAGC-TFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRT 551

  Fly   482 EESLDDDCWLHSGDLGFVDDKGYVSLTGRSKEIIITAGGENIPPVHIENTIKKELDAISNAFLVG 546
            :|:||.|.|||:||:|.....|.:.:..|.|.|...|.||.:.|..||| |......::..::.|
Human   552 KEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIEN-IYIRSQPVAQIYVHG 615

  Fly   547 EQRK-YLTVLITLKTEVDKDSGEPLDELSHESSVWVKSLGVEHKTVSDILAAGPCPKVWKSIEDA 610
            :..| :|..::....||              ...|.:..|:| .|.:|:.......|.  .:||.
Human   616 DSLKAFLVGIVVPDPEV--------------MPSWAQKRGIE-GTYADLCTNKDLKKA--ILEDM 663

  Fly   611 IKRANKQSISNAQKVQKFTILPHDFSIPTGELGPTLKVKRNVVSKMYADEIEKLYA 666
            ::...:..:.:.::|:...|....||:..|.|.||||.||..:.:.:..:||:||:
Human   664 VRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYS 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgm	NP_001285923.1	FAA1	32..666	CDD:223953	179/685 (26%)
bgm	NP_001285923.1	ACSBG_like	69..665	CDD:213299	167/631 (26%)
ACSL6	NP_001009185.1	PLN02736	97..719	CDD:178337	176/673 (26%)
ACSL6	NP_001009185.1	LC-FACS_euk	141..718	CDD:213293	166/628 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840