DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgm and ACSL4

DIOPT Version :9

Sequence 1:	NP_001285923.1	Gene:	bgm / 44117	FlyBaseID:	FBgn0027348	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_024308119.1	Gene:	ACSL4 / 2182	HGNCID:	3571	Length:	717	Species:	Homo sapiens

Alignment Length:	734	Identity:	172/734 - (23%)
Similarity:	292/734 - (39%)	Gaps:	156/734 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PNRLRQADAYRTTNRQDAVKIRMAKDGIGAEEPISVPG------LLKRTVNNYGDYPALRTK--- 68
            |...:....||:....|::.:            |.:||      |....|:.:|...:|.|:
Human    56 PTSDKPGSPYRSVTHFDSLAV------------IDIPGADTLDKLFDHAVSKFGKKDSLGTREIL 108

  Fly    69 --------NGK-------NGYHTVTYKQYEQKVHQVAKAFIKLGLEEHHSVGVLAFNCAEWFYSA 118
                    |||       ..|..:.|.:..::|:........|||:..:::.:.....|||..:|
Human   109 SEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAA 173

  Fly   119 MGAIHARGIIAGIYTTNSADAVQHVLESSHAQIVVVDDAKQMDKIHAIRDKLPKLKAAIQIQEPY 183
            .........:..:|.|...:||.|.|..|.|..::........|:......:..:|..|.:....
Human   174 QTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKA 238

  Fly   184 SPYLKKEDGYYRWSEIESMNVSDVEDQYMTRLENVAI-------NECCCLVYTSGTVGMPKGVML 241
            ....:..:|:    ||.||  ..|| :..:..||:.|       ::...::||||:.|.|||||:
Human   239 INKAEYPEGF----EIHSM--QSVE-ELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMM 296

  Fly   242 SHDNITFDVRGIVKAMDRV--VVGAESIVSYLPLSHVAAQTVDIYTCAFVAGC-------IWFAD 297
            .|.|:   :.|:....:|:  :...::.:.||||:||...|.:| :| |..||       :..:|
Human   297 HHSNL---IAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEI-SC-FTYGCRIGYSSPLTLSD 356

  Fly   298 -----KDALKG--TLVKSLQDARPTRFMGVPRVYEKFQERMVAVASSSGSLKKMLASWAKGITLK 355
                 |...||  |::|      ||....||.:.::..:.:::.......::|.|....     .
Human   357 QSSKIKKGSKGDCTVLK------PTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIG-----Y 410

  Fly   356 HYMVSQGKSSGGFRYKIAKSLIMSKVKQALGFDRVLTLASAAAPMSPETKKYF-LSLDLKIVDAF 419
            .|.:.|.|.  |:...:...|:..|||..|| ..|..:.|..||:||:|.::. :.....|...:
Human   411 DYKLEQIKK--GYDAPLCNLLLFKKVKALLG-GNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGY 472

  Fly   420 GMSETAGCHTICLPDSVGLNTIGKTLPGCESKF---------INKDANGHGELCIRGRHVFMGYI 475
            |::|:.|..|:..........:|..|..||.|.         ||...|..||:.|.|:::.|||.
Human   473 GLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYF 537

  Fly   476 DNKEKTEE--SLDDD--CWLHSGDLGFVDDKGYVSLTGRSKEIIITAGGENIPPVHIENTIKKEL 536
            .|:|||.|  |:|::  .|..:||:|.....|.:.:..|.|:::....||.:....:|..: |..
Human   538 KNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAAL-KNC 601

  Fly   537 DAISN--AFLVGEQ----------RKYLTVLITLKTEVDKDSGEPLDELSHESSVWVKSLGVEHK 589
            ..|.|  ||...:|          :|.||:|...|                         |||..
Human   602 PLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQK-------------------------GVEGT 641

  Fly   590 TVSDILAAGPC--PKVWKSIEDAIKRANKQSISNAQKVQKFTI------LPHDFSIPTGELGPTL 646
            .|.  :...|.  .::.|.|.:|         :||.|:::|.|      .|..::..||.:....
Human   642 WVD--ICNNPAMEAEILKEIREA---------ANAMKLERFEIPIKVRLSPEPWTPETGLVTDAF 695

  Fly   647 KVKRNVVSKMYADEIEKLY 665
            |:||..:...|..:||::|
Human   696 KLKRKELRNHYLKDIERMY 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgm	NP_001285923.1	FAA1	32..666	CDD:223953	168/715 (23%)
bgm	NP_001285923.1	ACSBG_like	69..665	CDD:213299	159/659 (24%)
ACSL4	XP_024308119.1	LC-FACS_euk	127..714	CDD:213293	156/649 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810