DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bgm and ACSL3

DIOPT Version :9

Sequence 1:	NP_001285923.1	Gene:	bgm / 44117	FlyBaseID:	FBgn0027348	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001341087.1	Gene:	ACSL3 / 2181	HGNCID:	3570	Length:	720	Species:	Homo sapiens

Alignment Length:	723	Identity:	158/723 - (21%)
Similarity:	293/723 - (40%)	Gaps:	134/723 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PNRLRQADAYRTTNRQDAVKIRMAKDGIGAEEPISVPG------LLKRTVNNYGDYPALRTK--- 68
            |...:...|||:.|         :.||:.:   :..||      :.....|.:.:...|.|:
Human    59 PVNSKPDSAYRSVN---------SLDGLAS---VLYPGCDTLDKVFTYAKNKFKNKRLLGTREVL 111

  Fly    69 --------NGK-------NGYHTVTYKQYEQKVHQVAKAFIKLGLEEHHSVGVLAFNCAEWFYSA 118
                    |||       ..|:.::|:....:..........||.:...::.:.....|||..:|
Human   112 NEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAA 176

  Fly   119 MGAIHARGIIAGIYTTNSADAVQHVLESSHAQIVVVDDAKQMDKIHAIRDKLPKLKAAIQIQEPY 183
            .........:..:|.|....|:.|.|..:....::........|:..|...:|:|:..|.:
Human   177 QACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITV---- 237

  Fly   184 SPYLKKEDGY-YRWSE------------IESMNV-SDVEDQYMTR--LENVAINECCCLVYTSGT 232
                   ||. ..|||            :|::.. :.:|:|..::  ..::|:     ::||||:
Human   238 -------DGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAV-----IMYTSGS 290

  Fly   233 VGMPKGVMLSHDNITFDVRGIVKAMDRV-VVGAESI-VSYLPLSHVAAQTVDIYTCAFVAGC-IW 294
            .|:|||||:||.||   :.||....:|: .:|.|.: :.||||:||...:.::...:.  || |.
Human   291 TGLPKGVMISHSNI---IAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSH--GCRIG 350

  Fly   295 FADKDAL--KGTLVK--SLQDA---RPTRFMGVPRVYEKFQERMVAVASSSGSLKKMLASWAKGI 352
            ::....|  :.:.:|  |..|.   :||....||.:.::..:.::...|...|.::.|  :....
Human   351 YSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNL--FILAY 413

  Fly   353 TLKHYMVSQGKSSGGFRYKIAKSLIMSKVKQALGFDRVLTLASAAAPMSPETKKYF-LSLDLKIV 416
            ..|...:|:|:::     .:..|.:..||:..|| ..:..|....||:|..|:::. :.....:.
Human   414 NYKMEQISKGRNT-----PLCDSFVFRKVRSLLG-GNIRLLLCGGAPLSATTQRFMNICFCCPVG 472

  Fly   417 DAFGMSETAGCHTICLPDSVGLNTIGKTLPGCESKFINKDANGH---------GELCIRGRHVFM 472
            ..:|::|:||..||..........:|..|..||.|..|.:..|:         ||:.|.|:.|.|
Human   473 QGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTM 537

  Fly   473 GYIDNKEKTEESLDDD----CWLHSGDLGFVDDKGYVSLTGRSKEIIITAGGENIPPVHIENTIK 533
            ||..|:.||:....:|    .||.:||:|..:..|.:.:..|.|:::....||.:....:|..:
Human   538 GYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAAL- 601

  Fly   534 KELDAISNAFLVGEQRKYLTVLITLKTEVDKDSGEPLDELSHESSV---W---VKSLGVEHKTVS 592
            |.|..:.|  :......|.:.:|.......|:    |.||:.:..:   |   ..|..:|:
Human   602 KNLPLVDN--ICAYANSYHSYVIGFVVPNQKE----LTELARKKGLKGTWEELCNSCEMEN---- 656

  Fly   593 DILAAGPCPKVWKSIEDAIKRANKQSISNAQKVQKFTILPHDFSIPTGELGPTLKVKRNVVSKMY 657
                     :|.|.:.:|   |...|:...:...|..:.|..::..||.:....|:||..:...|
Human   657 ---------EVLKVLSEA---AISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHY 709

  Fly   658 ADEIEKLY 665
            ..:||::|
Human   710 QADIERMY 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bgm	NP_001285923.1	FAA1	32..666	CDD:223953	153/704 (22%)
bgm	NP_001285923.1	ACSBG_like	69..665	CDD:213299	145/648 (22%)
ACSL3	NP_001341087.1	AFD_class_I	30..717	CDD:418409	157/721 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810