DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and CDC25

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_013413.1	Gene:	CDC25 / 851019	SGDID:	S000004301	Length:	1589	Species:	Saccharomyces cerevisiae

Alignment Length:	580	Identity:	126/580 - (21%)
Similarity:	229/580 - (39%)	Gaps:	122/580 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 ASNDS---DDEI--------------SHLEW------ETVRV----RFVKAATLARLVEALATDD 258
            :.||.   |||:              .:|.|      ||..|    ..::..|...|:|.|.:.
Yeast  1073 SENDEAIIDDELGSEDYIERKAANIEKNLPWFLTSDYETSLVYDSRGKIRGGTKEALIEHLTSH- 1136

  Fly   259 GELESTFINV-FLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIH 322
             ||.....|| .|.|:|:..|.::....|..||:....:.|               :||.:....
Yeast  1137 -ELVDAAFNVTMLITFRSILTTREFFYALIYRYNLYPPEGL---------------SYDDYNIWI 1185

  Fly   323 EQH----KKTLVSALHVWLDGF-PEDWHEDNLQQILAFA----TKRLKRSDLHIKVLNRLERLIK 378
            |:.    |..:|:.:..:|..: ..:::|..:..||.||    ::::..::..::.:|  |:||
Yeast  1186 EKKSNPIKCRVVNIMRTFLTQYWTRNYYEPGIPLILNFAKMVVSEKIPGAEDLLQKIN--EKLI- 1247

  Fly   379 QSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGP 443
                 |.......:......:||......:....|.|..||          .|........:|
Yeast  1248 -----NENEKEPVDPKQQDSVSAVVQTTKRDNKSPIHMSSS----------SLPSSASSAFFR-- 1295

  Fly   444 THFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARR--DSGGSETVVATINQFNAV 506
               |:..:...:....:|.|||.::.:|:.|:...:||...|..:  :.|||..:...|...| .
Yeast  1296 ---LKKLKLLDIDPYTYATQLTVLEHDLYLRITMFECLDRAWGTKYCNMGGSPNITKFIANAN-T 1356

  Fly   507 LFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPK 571
            |...||..::.:...:.|:.....::.:||..:.|.||||:.||:|||.|:.||||.|.|:::..
Yeast  1357 LTNFVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVST 1421

  Fly   572 ERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYL 636
            |..::...|.|:.....|....||:|:                           :.|....:|:.
Yeast  1422 ESKDLLKNLNNLMDSKRNFVKYRELLR---------------------------SVTDVACVPFF 1459

  Fly   637 GTFLTDLTMIHTANPDYL-TENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQ----ADALFDHW 696
            |.:|:|||.....|||:| ....:|||.|:.|...::.:|  :......|.|:    ...:.:..
Yeast  1460 GVYLSDLTFTFVGNPDFLHNSTNIINFSKRTKIANIVEEI--ISFKRFHYKLKRLDDIQTVIEAS 1522

  Fly   697 FNSMPVFDEREAFELSCRLEPPPPAPRKSVVSTNTSLTNTTASSTASIMGHRKTDSIHSN 756
            ..::|..:::  ::||.::|     ||......:|..::.:.:.||..:. ..||..:.|
Yeast  1523 LENVPHIEKQ--YQLSLQVE-----PRSGNTKGSTHASSASGTKTAKFLS-EFTDDKNGN 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	30/141 (21%)
		RasGEF	454..719	CDD:214539	67/271 (25%)
		RalGDS_RA	858..946	CDD:176351
CDC25	NP_013413.1	SH3_Sdc25	62..122	CDD:212816
		RasGEFN	1117..1246	CDD:214571	29/147 (20%)
		RasGEF	1301..1543	CDD:214539	68/278 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010