Protein Alignment Rgl and BUD5

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_009967.2
• Gene: BUD5 / 850405
• SGDID: S000000634
• Length: 642
• Species: Saccharomyces cerevisiae
• Alignment Length: 605
• Identity: 109/605 - (18%)
• Similarity: 216/605 - (35%)
• Gaps: 165/605 - (27%)

  Fly   139 YDDLDVSSAVLNAERKVVASLKYLCACTGATLRNLSKKTKDLHAKNYTYTKPTWRLWGEEHEKNA 203
            |:|..|...:|::.|..|..|....||..... .|.|:::|:...........:|| |.:...:|
Yeast    92 YNDNIVPKKILDSMRTAVRQLLEATACVSREC-PLVKRSQDIKRARKRLLSDWYRL-GADANMDA 154

  Fly   204 IFTVYLKKVRY---HRPTPTASNDSDDE----ISH-LEWETVRVRFVKAATLARLV----EALAT 256
            :..|.....|:   .||...:...:..|    |:| |....|.::.|.|  |.:||    :.|.:
Yeast   155 VLLVVNSAWRFLAVWRPFVNSIQHATQELYQNIAHYLLHGNVNIQRVTA--LIQLVMGQDDLLFS 217

  Fly   257 DDGELESTF-INVFLS-----------------------TYRTFSTPKQVLSLLTQRYDALHEKH 297
            .|..|:..| |.::|:                       .:|.::|...:|..|...|..:::..
Yeast   218 MDDVLQEVFRIQLYLNKMLPHNSHKWQKPSPFDSANLLLNFRDWTTDNALLQELLLSYPTINKNK 282

  Fly   298 LEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKR 362
                                    |:.|  ::...:.:|::.:.:| .|..|:.||.|....|..
Yeast   283 ------------------------HKNH--SVPRLIQIWVESYWQD-SETTLKDILNFWYSHLAE 320

  Fly   363 SDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFN 427
            ...:.::...:.:|                     :::..|::|::     .||   ..|||:..
Yeast   321 YYEYQELFADIVQL---------------------FINKKRTRQLK-----IHY---IGLTDKEI 356

  Fly   428 GMYLSPMGHGPIY----------------------------RGPTHFLQAFRFPHVPVRHFAEQL 464
            .....|:.:..::                            :|....::||.. :|.....|:.|
Yeast   357 EENKPPLDYENLFLQYEIDKTNANDELCGATDLSDLLFQWKQGELLEVEAFAL-NVSPWSLAKTL 420

  Fly   465 TRMDTELFKRLIPHQCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNIS 529
            |.:::.|:..:...:...|  .:.:....::|....||        :||.:::....|..  .||
Yeast   421 TLLESSLYLDIETIEFTRH--FKHNDTTIDSVFTLSNQ--------LSSYVLETTLQQTH--TIS 473

  Fly   530 RWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLR 594
            .|:.:|.....|:|.:||.:||::|.::||.|||...:|   :...:|..|..:...:||....|
Yeast   474 YWLQVALSCLYLRNLNSLASIITSLQNHSIERLSLPIDV---KSDHLFQRLKVVVHPNNNYNVYR 535

  Fly   595 EVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKL 659
            ..:|....::.|                         .:|:....:.|:|.|...|..:..:...
Yeast   536 RTIKHIFHSQLP-------------------------CVPFTSLLIRDITFIRDGNDTFTKDGNN 575

  Fly   660 INFDKKRKEFEVLAQIKLLQ 679
            :|..|..:..:::|..:.||
Yeast   576 VNMQKFNQITKIVAFAQYLQ 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	25/159 (16%)
		RasGEF	454..719	CDD:214539	46/226 (20%)
		RalGDS_RA	858..946	CDD:176351
BUD5	NP_009967.2	RasGEFN	230..339	CDD:214571	17/156 (11%)
		RasGEF	409..640	CDD:214539	46/228 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010