DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and Rasgef1c

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001334391.1	Gene:	Rasgef1c / 74563	MGIID:	1921813	Length:	469	Species:	Mus musculus

Alignment Length:	535	Identity:	121/535 - (22%)
Similarity:	197/535 - (36%)	Gaps:	127/535 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 PTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALA-TDDGELESTFINVFLSTYRTFSTPK 280
            |.||.|.:.:.     ..:.:......:|:|..|::.|. |.|...|..:|..||.:.|.|..|:
Mouse    21 PPPTESTEGEQ-----AGQPLLDGAPSSASLDTLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPR 80

  Fly   281 QVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWH 345
            ::|:.:.         || .:||.|.:..|:|     .|.:.:...| |:..|..|.:.||.|:.
Mouse    81 ELLARVC---------HL-CIEQQQLDKPVLD-----KARVRKFGAK-LLQLLAEWTETFPRDFE 129

  Fly   346 EDNLQQILAFATKRLKRSD-LHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQ 409
            |::....|.....|:...| .:...:::|.:.:.|.|...|.|.       .|.:.|.:
Mouse   130 EESTIGHLTDVVGRISPCDETYGSRVHQLLQTLHQKLASLGQGP-------ESLVGADK------ 181

  Fly   410 FMIPTHY----------------GSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVR 458
               |..|                ...|.|..|...:.|..:.|    .||..|:|||
Mouse   182 ---PISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRH----IGPEEFVQAF-------- 231

  Fly   459 HFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQE 523
                             :....|..| ..|.|..:..|.|.:..||.:.:.|.:.|.:. .|.::
Mouse   232 -----------------VNKDPLAGT-KPRFSDKTNNVEAYVKWFNRLCYLVATEICMP-AKKKQ 277

  Fly   524 RALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTE----LANIC 584
            ||..|..:||:|:|...:.||:||.||||.:|.:.:.||.|.|..:...:..:...    ..|.|
Mouse   278 RAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFFILEHQMDPTGNFC 342

  Fly   585 SEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTA 649
               |....||....|..||        ||.|  :|::           ||:....:.|:..::..
Mouse   343 ---NYRTALRGAAHRSLTA--------HSSR--EKIV-----------IPFFSLLIKDIYFLNEG 383

  Fly   650 NPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYN-----LQADALFDHWFNSMPVFDEREAF 709
            ..:.| .|..:||:   |..|:..|:    |...|:.     .:.|....|:..:.|:|.|...:
Mouse   384 CANRL-PNGHVNFE---KFLELAKQV----GEFITWKQVECPFEQDPSITHYLYTAPIFSEDGLY 440

  Fly   710 ELSCRLEPPPPAPRK 724
            ..|...|.|.....|
Mouse   441 LASYESESPESQTEK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	33/133 (25%)
		RasGEF	454..719	CDD:214539	62/273 (23%)
		RalGDS_RA	858..946	CDD:176351
Rasgef1c	NP_001334391.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910