Protein Alignment Rgl and Rgl3

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_076111.2
• Gene: Rgl3 / 71746
• MGIID: 1918996
• Length: 709
• Species: Mus musculus
• Alignment Length: 809
• Identity: 241/809 - (29%)
• Similarity: 357/809 - (44%)
• Gaps: 163/809 - (20%)

  Fly   195 WGEEHEKNAIFTVYLKKVRYHRPTPTASNDSDDEI----SHLEWETVRVRFVKAATLARLVEALA 255
            ||||.|..|:::|.|::.|..|.||..|.:....|    :.|.:.|.:||.::||.|.|||..|.
Mouse    17 WGEETEDGAVYSVSLRRQRSQRSTPERSGEGQTPIPATDTFLHYRTSKVRALRAARLERLVHELV 81

  Fly   256 TDDGELESTFINVFLSTYRTFSTPKQVLSLL------------------TQRYDALHEKHLEELE 302
            :.|.|.:..|:..||:|:|.|....:||..|                  |:..|....|:|
Mouse    82 SGDREQDPGFVPAFLATHRAFVPTARVLGFLLPPPPPPPPPPAGVDSKRTEGQDLNFSKNL---- 142

  Fly   303 QAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDW-----HED--NLQQILAFATKRL 360
                                    :.:||.|..||...|:|:     |::  |::..|.:|....
Mouse   143 ------------------------RAVVSVLGSWLRNHPQDFRDPPDHQNLGNVRIFLGWAAPGG 183

  Fly   361 KRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSY--DLT 423
            ..:       ...|:|::..| ....|....|....:|....|..|..        ||.:  |..
Mouse   184 AEA-------REAEKLLEDFL-KEAKGEQTEEEKRLAWSGPPRIAQTP--------GSEFAEDCV 232

  Fly   424 DQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARR 488
            ::          .||...||.  |..|....|     |||||.||.|||.|:...:|||..|::|
Mouse   233 EE----------EGPSSEGPE--LLDFSVDDV-----AEQLTLMDVELFLRVRSCECLGSMWSQR 280

  Fly   489 D----SGGSETVVATINQFNAVLFRVVSSIL-IDRLKPQERALNISRWIDIAQELRMLKNFSSLK 548
            |    :|.|.||.||:.|||.|...|:.|:| ...|...:||..|.:||.|||..|.|:|||||:
Mouse   281 DRPGAAGISPTVRATVAQFNTVTGCVLGSVLAAPGLAASQRAQRIEKWIRIAQRCRELRNFSSLR 345

  Fly   549 AIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHS 613
            ||:|||.||.||||.:.|..:.:|.:.||.:|:.|.|:::|..:.|.:|.:|.|.::.|..|.
Mouse   346 AILSALQSNPIYRLKRSWGAVSREPLSVFRKLSQIFSDEDNHLSSRAILSQEETTEDDDCPSG-- 408

  Fly   614 DRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLL 678
                     :|.::...|.:||||||||||.|:.||.||.|..| ||||:|:|||:|:||:|:.|
Mouse   409 ---------SLPSKLPPGPVPYLGTFLTDLVMLDTALPDTLKGN-LINFEKRRKEWEILARIQQL 463

  Fly   679 QGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPP----PPAPRKSVVSTNTSLTNTTAS 739
            |.....|:|...........:.....|.:::.:|..:|||    |.:||   :....|||...::
Mouse   464 QQRCQRYSLSPRPPILAALRAQRQLSEEQSYRVSRVIEPPAASCPSSPR---IRRRISLTKRLSA 525

  Fly   740 STASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLD 804
            ..          |...|||.|....   :.:|.|||             .|..|..||..|....
Mouse   526 KL----------SREKNSSPGGSPG---DPSSPTSS-------------VSPGSPPSSPRNREPP 564

  Fly   805 SSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSSGTP---HSAPDFYIIRVTY 866
            ...|.....|..:.|..:...:...|.....         |...||..|   ....:..:|||:.
Mouse   565 PPGSPPASPGPQSPSTKLSLTMDPPGPWPVT---------LTPSSSRVPLLGQQTSEARVIRVSI 620

  Fly   867 ETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDDPDR-FTLAQVLP-DKELVMPKNANV 929
            ..::..     ||:||:|...::.|.|::.|:.|..:.....| :.|.|||| |:||::|..|||
Mouse   621 NNNHGN-----LYRSILLTCQDKAPSVVQRALEKHNVPQPWARDYQLFQVLPGDRELLIPDGANV 680

  Fly   930 YYAVNTNYNLNFILRPRKEEGVAGSXSTA 958
            :||::.....:|:|  |::||...: |.:
Mouse   681 FYAMSPAAPGDFLL--RRKEGTGHTLSAS 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	33/156 (21%)
		RasGEF	454..719	CDD:214539	112/273 (41%)
		RA_RalGDS_like	858..946	CDD:340449	29/89 (33%)
Rgl3	NP_076111.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..55		8/28 (29%)
		REM	73..199	CDD:100121	34/161 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..225		4/29 (14%)
		RasGEF	244..503	CDD:214539	112/275 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..416		5/31 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..604		29/139 (21%)
		Interaction with HRAS, MRAS and RIT1. /evidence=ECO:0000269|PubMed:10869344, ECO:0000269|PubMed:11313946	611..706		32/101 (32%)
		RA_RGL3	611..697	CDD:340732	30/92 (33%)