DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and Rasgef1a

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001349032.1	Gene:	Rasgef1a / 70727	MGIID:	1917977	Length:	498	Species:	Mus musculus

Alignment Length:	530	Identity:	117/530 - (22%)
Similarity:	203/530 - (38%)	Gaps:	126/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 AATLARLVEALA-TDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQN 307
            :.:|..|:|.|. |.|...:.|:|..||.:.|.|..|..:|:.:.|..          |||.||
Mouse    55 SGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQIC----------LEQRQQ- 108

  Fly   308 GQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHI----- 367
               ::..  |..:..:.....:|..|..|.:.||.|:.::.:...|.....|:.:.|.::
Mouse   109 ---LEAG--PEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKVMAELKAIAHRVTQCDEYLMQPRP 168

  Fly   368 -----KVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFN 427
                 .|...:.::|:..|                 ||.|...|:|            :|.::..
Mouse   169 SQENGTVKKAIAQMIQSLL-----------------LSLAARSQLQ------------ELREKLR 204

  Fly   428 GMYLSP-MGHGPIYR-----GPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIP--------- 477
                || :..||:.:     .....|.....|.|    .|:|||.::.|....:.|
Mouse   205 ----SPVVDKGPVLKAKPPAAQKDILGVCSDPLV----LAQQLTHIELERVNSIRPEDLMQIISH 261

  Fly   478 ------HQCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQ 536
                  |:|.|      |...:.::.|..|.||. |..:|::.:...:|.:.|...:..:||:|:
Mouse   262 MDSLDNHRCRG------DMTKTFSLEAYDNWFNC-LSMLVATEVCRVVKKKHRTRMLEFFIDVAR 319

  Fly   537 ELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTE----LANICSEDNNAWTLREVL 597
            |...:.||:|:.||||.:|.:.:.||.|.|..:...:.:|...    .:|.|   |....|:...
Mouse   320 ECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFC---NYRTALQGAT 381

  Fly   598 KREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINF 662
            :|..||        :|.|  :|::           ||....|:.|:..:|..:.::| .|..|||
Mouse   382 QRSQTA--------NSSR--EKIV-----------IPVFNLFVKDIYFLHKIHTNHL-PNGHINF 424

  Fly   663 DKKRKEFEVLAQI-KLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRK-S 725
               :|.:|:..|| :.:.........:.|.....:..:.|::.|...|..|...|.|.....| |
Mouse   425 ---KKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEALFIASFESEGPENHMEKDS 486

  Fly   726 VVSTNTSLTN 735
            ..:..|:|.|
Mouse   487 WKALRTTLLN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	31/142 (22%)
		RasGEF	454..719	CDD:214539	66/284 (23%)
		RalGDS_RA	858..946	CDD:176351
Rasgef1a	NP_001349032.1	REM	57..163	CDD:100121	30/121 (25%)
Rasgef1a	NP_001349032.1	RasGEF	235..427	CDD:306970	55/226 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910