Protein Alignment Rgl and rgl2

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_005158441.1
• Gene: rgl2 / 65227
• ZFINID: ZDB-GENE-010131-1
• Length: 744
• Species: Danio rerio
• Alignment Length: 812
• Identity: 241/812 - (29%)
• Similarity: 394/812 - (48%)
• Gaps: 156/812 - (19%)

  Fly   173 LSKKTKDLHAKNYTYTKP-----TW------RLWGEEHEKNAIFTVYLKKVRYHRP-TPTASNDS 225
            |.|:::...|.::|..:|     ||      ....|..|...|:||.:|:    .| :||:...:
Zfish    40 LWKESEHREADHHTQGEPSPMKTTWYCPLDLSTVSEMEEDGIIYTVVVKQ----GPGSPTSPQST 100

  Fly   226 DDEISHLEWETVRVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRY 290
                      ..|.:.|||.|..:||..|.......:|:||::||||||:|::.::||.:|..|.
Zfish   101 ----------AARSQHVKAGTEEKLVLHLLHSFSMGDSSFISIFLSTYRSFTSTQRVLDILICRL 155

  Fly   291 DALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHE----DNLQQ 351
            :                    :|..:.|::..:...|.:.:....|:..:|||:..    ..|.:
Zfish   156 E--------------------NPPGESHSNSRQMFNKAVCTVFSTWMTDYPEDFRSLSDPSRLLR 200

  Fly   352 ILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHY 416
            :..........:::..::|...|.|.:::|                 |||:.|...:..:.|.:
Zfish   201 LAPLLPTDSSGAEIKSRLLRIAEELSEKTL-----------------LSASLSDPTKGLLSPPN- 247

  Fly   417 GSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCL 481
            .|.:|.|        |.:|                ||...:   ||||||::|:||.:|:||.||
Zfish   248 PSDFDAT--------SVLG----------------FPSSVI---AEQLTRIETDLFLKLVPHHCL 285

  Fly   482 GHTWARRDSGGSE----TVVATINQFNAVLFRVVSSIL-IDRLKPQERALNISRWIDIAQELRML 541
            |..|::||..|.|    :|.|||.|||.:...|.:|.| :..||.|:||..:.:||.:|:..|..
Zfish   286 GSLWSQRDKKGQEGACWSVRATIKQFNRLANAVTASCLWMTTLKSQQRARLLEKWISVAEACRTR 350

  Fly   542 KNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNP 606
            ||||||.||:|||.||.|:||.|.|:...:|.::.:.||::|.||.:|....||:||.|||:|..
Zfish   351 KNFSSLYAILSALQSNPIHRLRKTWQETDREAVKRYEELSDIFSEKDNYSQSRELLKEEGTSKFA 415

  Fly   607 DPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEV 671
            :..:..::|...       ...:.||:||||.||.||||:.||..|.| ||..|||||:|:||||
Zfish   416 NHDTKINNRRFT-------GSCAQGTVPYLGIFLRDLTMLDTAVKDRL-ENGFINFDKRRREFEV 472

  Fly   672 LAQIKLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPP-PPAPRKSVVSTNTSLTN 735
            :|||:|||.:......:.|..|.||::|:|...|.|:::||.::|.| .|:|.:.:   |.::..
Zfish   473 IAQIRLLQSSCKNSIFRTDETFIHWYHSVPTLREEESYKLSNQIEAPGEPSPGRGL---NPTVII 534

  Fly   736 TTASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSN 800
            |......|.:         :|::..|...|  :..|..:...:.|.:.|         .|.|||.
Zfish   535 TQCPDALSAV---------ANTTMDADGIF--DFPSPVNQLLSKLCKHV---------KSPSVSC 579

  Fly   801 LSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSSGTPHSAPDFYIIRVT 865
            |.:|||......:..:..:.:  ..:|||....:.|.:         |::..|.:.||..|:|:
Zfish   580 LDVDSSPPSNDSTPSILTTPT--TAVKSHRRSVSCGNN---------PTNSKPEAGPDMRIVRI- 632

  Fly   866 YETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLE-DDPDRFTLAQVLPD-KELVMPKNAN 928
                .::|....||:||::.:|::||.||.:|:.|.... .:..::.|.|:||: |||::|...|
Zfish   633 ----RMDLHDGNLYRSILVTSNDKTPTVISSALEKHNQNAQEASKYELIQLLPEGKELIIPPTGN 693

  Fly   929 VYYAVNTNYNLNFILRPRKEEGVAGSXSTAVP 960
            |:||: ::.:::|:||.|     .|: .|..|
Zfish   694 VFYAM-SSASVDFLLRRR-----GGNTPTGSP 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	29/135 (21%)
		RasGEF	454..719	CDD:214539	119/270 (44%)
		RA_RalGDS_like	858..946	CDD:340449	30/89 (34%)
rgl2	XP_005158441.1	REM	111..>190	CDD:100121	25/98 (26%)
		RasGEF	256..519	CDD:214539	121/289 (42%)
		RA_RGL2	625..710	CDD:340731	31/90 (34%)