Protein Alignment Rgl and RGL2

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_047275155.1
• Gene: RGL2 / 5863
• HGNCID: 9769
• Length: 800
• Species: Homo sapiens
• Alignment Length: 834
• Identity: 252/834 - (30%)
• Similarity: 363/834 - (43%)
• Gaps: 198/834 - (23%)

  Fly   194 LWGEEHEKNAIFTVYLKKVR-----YHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLV-E 252
            :|.|| |..|:|||..::.|     ...|.|.:|                 |.::|.||..|| .
Human    80 VWDEE-EDGAVFTVTSRQYRPLDPLVPMPPPRSS-----------------RRLRAGTLEALVRH 126

  Fly   253 ALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDP 317
            .|.|.....:.:|::.||:|:|.|::...:|.|:..|.:||.....:|||:..:
Human   127 LLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELERTTE----------- 180

  Fly   318 HASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLY 382
                      ..:|.|..||...|||:..:...|                  |:|||..:.|:.|
Human   181 ----------VAISVLSTWLASHPEDFGSEAKGQ------------------LDRLESFLLQTGY 217

  Fly   383 GNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFL 447
            ..|.|.||.        ||...:.::..:.|    .:.||...     |:..|..|  ..||..|
Human   218 AAGKGVGGG--------SADLIRNLRSRVDP----QAPDLPKP-----LALPGDPP--ADPTDVL 263

  Fly   448 QAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATINQFNAVLF 508
            ...      ..|.|||||.:|.|||..|||.||||..|..||..|..    :|.||:.|||.|..
Human   264 VFL------ADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAG 322

  Fly   509 RVVSSIL-------------IDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIY 560
            .||||:|             |..|:|.:||..:.:||.:|:|.|:|:||||:.|::|||.|:.|:
Human   323 AVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 387

  Fly   561 RLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNP-DPGSDHSDRHLQKLILNL 624
            ||...|....::.:.||:.|..|.||::|....||:|.:|...::| :|.|..:.|.
Human   388 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRS-------- 444

  Fly   625 GTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQA 689
            |:: ..|.:|||||||.||.|:..|:.|.| ||..|||||:||||.||::::.||.....||||.
Human   445 GSR-GGGVVPYLGTFLKDLVMLDAASKDEL-ENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 507

  Fly   690 DALFDHWFNSMPVFDEREAFELSCRLEPP----PPAPR--------------KSVVSTNTSLTNT 736
            |.....|...:....|.::..:||.:|||    |||||              ...|...|.|.:.
Human   508 DHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSC 572

  Fly   737 TASSTAS-------------IMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQH 788
            ...||..             :..|.|..|:.|..|:         |.|| .|.|:..|    ..|
Human   573 DRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSA---------LESS-PSLHSPAD----PSH 623

  Fly   789 ASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSSGTP 853
            .|..::|...|.....|::.|...||          |.:....||..||            .|:.
Human   624 LSPPASSPRPSRGHRRSASCGSPLSG----------GAEEASGGTGYGG------------EGSG 666

  Fly   854 HSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDD--PDRFTLAQVL 916
            ..|.|..||||..|...   ||.| ||||::.:.::.|.|| :.:||....|.  ...:.|.|:|
Human   667 PGASDCRIIRVQMELGE---DGSV-YKSILVTSQDKAPSVI-SRVLKKNNRDSAVASEYELVQLL 726

  Fly   917 P-DKELVMPKNANVYYAVNTNYNLNFILRPRKEEGVA------GSXSTAVPLSQ 963
            | ::||.:|.:|||:||:: ..:.:|:||.|:....|      |. ::..|.|:
Human   727 PGERELTIPASANVFYAMD-GASHDFLLRQRRRSSTATPGVTSGPSASGTPPSE 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	32/132 (24%)
		RasGEF	454..719	CDD:214539	114/286 (40%)
		RA_RalGDS_like	858..946	CDD:340449	34/90 (38%)
RGL2	XP_047275155.1	RasGEFN	113..235	CDD:214571	42/168 (25%)
		RasGEF	262..536	CDD:214539	113/289 (39%)
		RA_RGL2	670..756	CDD:340731	34/91 (37%)