DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and RGL3

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001155088.2	Gene:	RGL3 / 57139	HGNCID:	30282	Length:	716	Species:	Homo sapiens

Alignment Length:	825	Identity:	246/825 - (29%)
Similarity:	367/825 - (44%)	Gaps:	188/825 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 WGEEHEKNAIFTVYLKKVRYHR------------PTPTASNDSDDEISHLEWETVRVRFVKAATL 247
            ||||.|..|:::|.|::.|..|            |:|.|:       :.|.:.|.:||.::||.|
Human    17 WGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIAN-------TFLHYRTSKVRVLRAARL 74

  Fly   248 ARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMD 312
            .|||..|...|.|.:.:|:..||:|||||.....:|..|.                     ..|.
Human    75 ERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLL---------------------PPMP 118

  Fly   313 PAYDPHASIHE---------QHKKTLVSALHVWLDGFPEDW-----HED--NLQQILAFATKRLK 361
            |...|...|.:         ::.:.:||.|..||...|:|:     |.|  :::..|.:|.....
Human   119 PPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDHPAHSDLGSVRTFLGWAAPGSA 183

  Fly   362 RSDLHIKVL-NRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQ 425
            .:....|:| :.||...::.          .|.....|....|..|...   |   .||....::
Human   184 EAQKAEKLLEDFLEEAEREQ----------EEEPPQVWTGPPRVAQTSD---P---DSSEACAEE 232

  Fly   426 FNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRD- 489
            ..|:    |..||         |...|   .|...|||||.:|.|||.::..::|||..|::||
Human   233 EEGL----MPQGP---------QLLDF---SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDR 281

  Fly   490 ---SGGSETVVATINQFNAVLFRVVSSIL-IDRLKPQERALNISRWIDIAQELRMLKNFSSLKAI 550
               :|.|.||.||:.|||.|...|:.|:| ...|...:||..:.:||.|||..|.|:|||||:||
Human   282 PGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAI 346

  Fly   551 ISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPD-----PGS 610
            :|||.||.||||.:.|..:.:|.:..|.:|:.|.|::||..:.||:|.:|...:...     |||
Human   347 LSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGS 411

  Fly   611 DHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQI 675
                         |.::...|.:||||||||||.|:.||.||.| |..||||:|:|||:|:||:|
Human   412 -------------LPSKPPPGPVPYLGTFLTDLVMLDTALPDML-EGDLINFEKRRKEWEILARI 462

  Fly   676 KLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPP----PPAPRKSVVSTNTSLTNT 736
            :.||....:|.|..........::.....|.:::.||..:|||    |.:||   :....|||..
Human   463 QQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPR---IRRRISLTKR 524

  Fly   737 TASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNL 801
            .::..|           ...|||.:||.  .:.:|.|||                :..|.|||
Human   525 LSAKLA-----------REKSSSPSGSP--GDPSSPTSS----------------LCISPSVS-- 558

  Fly   802 SLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSS-------GTP------ 853
                  .|...|...:.....|:...|.|   ..|.|..:...|..||.       |:|
Human   559 ------PGSPPSSPRSRDAPAGSPPASPG---PQGPSTKLPLSLDLPSPRPFALPLGSPRIPLPA 614

  Fly   854 HSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDDPD----RFTLAQ 914
            ..:.:..:|||:.:.|:..     ||:||:|.:.::.|.|:|.|:.|   .:.|.    .:.|.|
Human   615 QQSSEARVIRVSIDNDHGN-----LYRSILLTSQDKAPSVVRRALQK---HNVPQPWACDYQLFQ 671

  Fly   915 VLP-DKELVMPKNANVYYAVNTNYNLNFILRPRKEEGVAGSXSTA 958
            ||| |:.|::|.||||:||::.....:|:|  |::||...:.|.:
Human   672 VLPGDRVLLIPDNANVFYAMSPVAPRDFML--RRKEGTRNTLSVS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	36/148 (24%)
		RasGEF	454..719	CDD:214539	111/278 (40%)
		RalGDS_RA	858..946	CDD:176351	31/92 (34%)
RGL3	NP_001155088.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54		5/25 (20%)
		REM	74..196	CDD:100121	34/142 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..234		7/51 (14%)
		RasGEF	243..505	CDD:214539	110/278 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..419		4/34 (12%)
		Interaction with HRAS, MRAS and RIT1. /evidence=ECO:0000250	618..713		34/104 (33%)
		RalGDS_RA	619..704	CDD:176351	32/94 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I3069
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116220at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1296
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.880