DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rgl and Rapgef4

DIOPT Version :9

Sequence 1:NP_001261814.1 Gene:Rgl / 44115 FlyBaseID:FBgn0026376 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_001191094.1 Gene:Rapgef4 / 56508 MGIID:1917723 Length:1011 Species:Mus musculus


Alignment Length:695 Identity:135/695 - (19%)
Similarity:247/695 - (35%) Gaps:210/695 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 HSYDDLDVSSAVLNAERKVVASLKY-LCACTGATLRNLSKKTKDLHAKNYTYTKPTWRLWGEEHE 200
            |..||....:.|.:|.|.....|:. .|........:.::..:|:.|.       |.||  :||:
Mouse   416 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEAN-------TVRL--KEHD 471

  Fly   201 KNAIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGELEST- 264
            ::.:   .|:||      |..:..::...|..:.:...:.......|...:|.:..:....|:| 
Mouse   472 QDVL---VLEKV------PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATD 527

  Fly   265 -FINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKT 328
             .:|.|:..:..|....|:...|...|   |.:..:..||.:     ||.|.:        :|:.
Mouse   528 SVLNDFVMMHCVFMPNTQLCPALVAHY---HAQPSQGTEQER-----MDYALN--------NKRR 576

  Fly   329 LVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKV-------------LNRLERLIKQ- 379
            ::..:..|...:.:...||::  .:||.      .:.::.|             |..||:::|| 
Mouse   577 VIRLVLQWAAMYGDLLQEDDV--AMAFL------EEFYVSVSDDARMMAAFKEQLPELEKIVKQI 633

  Fly   380 ---------------------------------------SLY----------------------- 382
                                                   .:|                       
Mouse   634 SEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISA 698

  Fly   383 -----GNGGG-------SGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDL-TDQFNGMYLSPM 434
                 |:|.|       |||.:       ...:|..:..|...|..|..:.. .:||:.  |:|:
Mouse   699 VADKLGSGEGLIIVKMNSGGEK-------VVLKSNDVSVFTTLTINGRLFACPREQFDS--LTPL 754

  Fly   435 GHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRD-SGGSETVVA 498
               |...|||..... .|..:..:..|.|:|..|.|||..:...:.:.||:.|.: ...:..:..
Mouse   755 ---PEQEGPTTGTVG-TFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDL 815

  Fly   499 TINQFNAVLFRVVSSI-LIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRL 562
            .:.:||.:.|.||:.: |..:|  .:|...:.::|.||...:..||.:|..||:..|::.::.||
Mouse   816 FLRRFNEIQFWVVTEVCLCSQL--SKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRL 878

  Fly   563 SKIWEVLPKERMEVFTELANIC--SEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLG 625
            :..||.||.:..:.:.|..::.  |.::.|:.|        ||...:|                 
Mouse   879 ALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRL--------TAAKLEP----------------- 918

  Fly   626 TQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANT---YNL 687
                 ..||::...:.|:|..|..|..::  :.|:||:|.|          ::...|.|   |..
Mouse   919 -----PLIPFMPLLIKDMTFTHEGNKTFI--DNLVNFEKMR----------MIANTARTVRYYRS 966

  Fly   688 Q------ADALFDH-----WFNSMPVFD-EREAFELSCRLEPPPP 720
            |      |.|..:|     :...:.|.| :|...::|.||||..|
Mouse   967 QPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RglNP_001261814.1 REM 246..378 CDD:100121 26/146 (18%)
RasGEF 454..719 CDD:214539 66/283 (23%)
RalGDS_RA 858..946 CDD:176351
Rapgef4NP_001191094.1 Crp 38..>158 CDD:223736
CAP_ED 43..158 CDD:237999
DEP_Epac 206..334 CDD:239884
Crp 351..>458 CDD:223736 8/41 (20%)
CAP_ED 356..467 CDD:237999 11/57 (19%)
RasGEF_N 499..605 CDD:279012 22/129 (17%)
RasGEF 768..1009 CDD:214539 66/284 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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