DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and sos2

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001334612.1	Gene:	sos2 / 561670	ZFINID:	ZDB-GENE-090319-5	Length:	1341	Species:	Danio rerio

Alignment Length:	863	Identity:	173/863 - (20%)
Similarity:	314/863 - (36%)	Gaps:	278/863 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CPHSQKHQQKPALIKSHTCAYQLQDLT-GYNRA--------LMPPLDNTDFSNAWRQVNNNTTSQ 66
            |.|......:|      |.|...|.:. |:..|        :|.|:
Zfish   303 CQHFNTLMSRP------TVALHFQSIAEGFKEAVQYVLPQLMMVPV------------------- 342

  Fly    67 SCAYH--------QQRQQQQQQQDAKDSKRHYHHHTCPRQRKKSMTPVEPT--HLCQKHQEAKQR 121
               ||        ||.|:..::||.::         |.:|.:.::..::.:  .:..|||..:::
Zfish   343 ---YHCIHYFELLQQLQECSEEQDDRE---------CLKQAQTALINLQCSIERIYAKHQPRRKQ 395

  Fly   122 ------------RSRSASAKPRRNSSYHSYDDLD------------VSSAVLNAERK------VV 156
                        ||:.|:.| |.|....|.|..:            :..|:|.|..|      :.
Zfish   396 GEPLYRLYSRASRSKQAAIK-RMNDIQKSIDGWEGKDIGQCCSQFILEGALLRAGAKHERHNFLF 459

  Fly   157 ASLKYLC----------ACTGATLRNLSK----KTKDLHAKNYTYTKPTWRLWGEEHEKNAIFT- 206
            ..|...|          |.:||..|...|    |.:.:..::....:..:.|.|.| |..|:|:
Zfish   460 DGLMISCKANQSSRLPGAGSGAEFRLKEKFVLRKYRIVDREDSPEFRHAFELVGRE-ESGAVFSA 523

  Fly   207 ----------VYLKKVRY------------HR---------PTPT----ASNDSDDEISHLEWET 236
                      ..|..::|            ||         |:|.    |..||::.|...|...
Zfish   524 RSAEEKSAWMAALVTLQYRPTLDRMLDTVLHREEQAQPLRLPSPDVYRFAIQDSEENIVFEEGAQ 588

  Fly   237 VR--VRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLE 299
            .:  :..:||.|:.:|:|.| |.....:..|:..||:|||:|..|:.:|:||.:|.:....:..|
Zfish   589 SKTGIPIIKAGTVVKLIERL-TYHMYADPNFVRTFLTTYRSFCKPQDLLTLLIERIEIPEPEPSE 652

  Fly   300 ELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHV--------WLDGFPEDWHED-----NLQQ 351
            ...:|..||:      .|.|:..::.::..|..:.:        |::....|:..|     .|:.
Zfish   653 ADREALWNGE------QPMAAELQRFRREYVQPVQLRVLNVFRQWVEHHFYDFENDPELYERLEG 711

  Fly   352 ILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHY 416
            .| .:|.:|:...:. |.:..:.:::::.:                        |||.      .
Zfish   712 YL-ISTTQLRGKSMR-KWVESISKIMRRKI------------------------QMQS------N 744

  Fly   417 GSSYDLT------------------DQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQ 463
            |.|:::|                  |.|:.|.|.|:                        ..|.|
Zfish   745 GISHNITFESPPPPIEWHISRPGQVDTFDLMTLHPI------------------------EIARQ 785

  Fly   464 LTRMDTELFKRLIPHQCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNI 528
            ||.::::|::.:.|.:.:|..|.:.|...:...:..:.:....|.......:::.....||....
Zfish   786 LTLLESDLYRAVRPSELVGSVWTKEDKEKNSPNLLRMIRHTTNLTLWFEKCIVEAENVDERVAVF 850

  Fly   529 SRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTL 593
            ||.|:|.|..:.|.||:.:..|:||:||..:|||...:|.:|:.:..:..|...:
Zfish   851 SRIIEILQVFQELNNFNGVLEIVSAINSVPVYRLDHTFEAVPERKRRILEEAVEL---------- 905

  Fly   594 REVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTEN- 657
                           ..||..::|.||     ...:...:|:.|.:||::......|||:|..:
Zfish   906 ---------------SQDHFKKYLAKL-----KSINPPCVPFFGIYLTNILKTEEGNPDFLKRDG 950

  Fly   658 -KLINFDKKRKEFEVLAQIKLLQGAANTYNLQAD--ALFDHWFNSMPVFDERE----AFELSCRL 715
             :||||.|:||..|:..:|:..|.......::.|  ..|:: .|.|...:|::    .|..|..:
Zfish   951 KELINFSKRRKVAEITGEIQQYQNQPYCLKVEHDIKRFFEN-LNPMGNMNEKDFSDYLFNKSLEI 1014

  Fly   716 EP-----PPPAPRKSVVS 728
            ||     ||..|||:..|
Zfish  1015 EPRNSKQPPRFPRKTTYS 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	32/144 (22%)
		RasGEF	454..719	CDD:214539	63/277 (23%)
		RalGDS_RA	858..946	CDD:176351
sos2	NP_001334612.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910