Protein Alignment Rgl and rasgrp4

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_005173714.1
• Gene: rasgrp4 / 558453
• ZFINID: ZDB-GENE-050419-110
• Length: 725
• Species: Danio rerio
• Alignment Length: 545
• Identity: 110/545 - (20%)
• Similarity: 192/545 - (35%)
• Gaps: 151/545 - (27%)

  Fly   290 YDALHEKHLEELEQAQQNGQVMD--PAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQI 352
            :|.::.|..:...:::|.|.:..  |.         |.:.|..||                 |:|
Zfish     3 FDTMNRKESKSSRKSRQEGGIKSRRPV---------QRRMTCPSA-----------------QEI 41

  Fly   353 LAFATKRLKRSDLHIKVLN-RLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTH- 415
                ::.|:....|....: .|:.||.:.|:  ...|.|..|.|...:|  .:..|..:::|:|
Zfish    42 ----SRALQSPPAHASFRSASLDELILRCLH--CFDSDGKLNRGTQLVS--MTLMMHNWVVPSHI 98

  Fly   416 ------------------------------YGSSYDLTDQFNGMYLSPMG--------------- 435
                                          :.|.:.|..:.:.:....||
Zfish    99 FAHKLLSLYKDCPAEKRGQRRPQICHFIRQWISQFRLMFEMDPLLEKAMGDLWALVSAEGTNSHH 163

  Fly   436 ---HGPIYRGPTHFLQ-----------AFRFPHVPVRHFAEQLTRMDTELF--------KRLIPH 478
               :.|....|.:..|           :..|.|:.....||.|:.::.:.|        :..:.|
Zfish   164 QLINTPYINPPVNISQTPSPLVKKRKVSLLFDHMEPDEMAEHLSYLEFKNFCNVSFLDYRSYVVH 228

  Fly   479 QCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKN 543
            ..:      ||:...|..|...|..:    :.|..::::|...|:||...:::|.:||:||.|:|
Zfish   229 GSV------RDNPALERSVMLCNGVS----QWVQLMILNRHTSQQRAEVFTKFIHVAQKLRSLQN 283

  Fly   544 FSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDP 608
            |::|.|:|..|..:||.||.....:|..:..:..:||..:.|..:|....|.|.
Zfish   284 FNTLMAVIGGLCHSSISRLKDTASLLSSDVTKTLSELTELLSSYSNYSNYRRVY----------- 337

  Fly   609 GSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLA 673
                             ::.:...:|.||..|.||..::.|.||||.::| ||..|.:..:..::
Zfish   338 -----------------SECTGFKVPILGVHLKDLISLNEALPDYLEDDK-INLGKLQHLYSNIS 384

  Fly   674 QIKLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEP-----PPPAPRKSVVSTNTSL 733
            .:..:......:....|.|.....:....:.|.|.:|||...||     .|.||.|..|......
Zfish   385 DLLAIHDCTPPFEANKDLLHLLTLSLDLYYTEDEIYELSYAKEPKNPKIQPVAPVKPPVVAEWGS 449

  Fly   734 TNTTASSTASIMGHRK--TDSIHSN 756
            ..|.....|:|..|.|  .|||..|
Zfish   450 GVTPRLDPATISKHVKQMVDSIMKN 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	15/90 (17%)
		RasGEF	454..719	CDD:214539	63/277 (23%)
		RalGDS_RA	858..946	CDD:176351
rasgrp4	XP_005173714.1	REM	58..162	CDD:100121	16/107 (15%)
		RasGEF	194..430	CDD:214539	64/274 (23%)
		EF-hand_7	473..519	CDD:290234	1/2 (50%)
		EFh	475..524	CDD:298682	110/545 (20%)
		C1_1	537..586	CDD:278556

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910