Protein Alignment Rgl and sos1

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001428581.1
• Gene: sos1 / 556286
• ZFINID: ZDB-GENE-070209-128
• Length: 1317
• Species: Danio rerio
• Alignment Length: 825
• Identity: 170/825 - (20%)
• Similarity: 297/825 - (36%)
• Gaps: 287/825 - (34%)

  Fly   111 LCQKHQEAKQRRSRSASAKPRRNSSY------------------HSYDDL--DVSSAVL---NAE 152
            :|.|....:.|...:::|:.|....:                  |:::.:  |.:|.|.   :||
Zfish   469 ICCKSNHGQPRLPGASAAEYRLKEKFFMRKVQINDKDDKEGEYRHAFEIILKDGNSVVFSAKSAE 533

  Fly   153 RK-----VVASLKYLCACTGATLRNL-------SKKTKDLH---AKNYTYTKPTWRLWGEEHEKN 202
            .|     .:.||:|     .:||..:       .:|.:.:.   |:.|.:.:|       :.|:|
Zfish   534 EKNGWMAALISLQY-----RSTLERMLDTAMLQEEKEEQMRLPGAQLYRFAEP-------DSEEN 586

  Fly   203 AIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVR----VRFVKAATLARLVEALATDDGELES 263
            .:|.                            |.|:    :..:||.|:.:|:|.| |.....:.
Zfish   587 VVFE----------------------------ENVQSKSGIPIIKAGTVLKLIERL-TFHMYADP 622

  Fly   264 TFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKT 328
            .|:..||:|||:|..|:::|.||.:|::....|..|..:.|.:||.      .|.::..::.:|.
Zfish   623 NFVRTFLTTYRSFCKPQELLDLLIERFEIPEPKPTEADQMALENGD------QPLSAELKRFRKE 681

  Fly   329 LVSALHV--------WLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNG 385
            .|..:.:        |::....|:..|                   .::|.|||..|     |..
Zfish   682 FVQPVQLRVLNVCRHWVEHHFYDFERD-------------------AQLLRRLEEFI-----GTV 722

  Fly   386 GGSGGSENNGHSWLSA-----ARSQQMQQFMIPTHYGSSYDLT------------------DQFN 427
            .|..     ...|:.:     .|.:|.|.      .|||:::|                  :||:
Zfish   723 RGKA-----MRKWVESITKIIQRKKQAQA------SGSSHNITFESSPPAIEWHLCRAGQVEQFD 776

  Fly   428 GMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGG 492
            .|.|.|:                        ..|.|||.::::.::.:.|.:.:|..|.:.|.
Zfish   777 LMTLHPI------------------------EIARQLTLLESDFYRAVQPSELVGSVWTKEDK-- 815

  Fly   493 SETVVATINQFNAVLFRVV----------SSILIDRLKPQERALNISRWIDIAQELRMLKNFSSL 547
                  .||..|  |.|::          ...:::....:||...:||.|:|.|..:.|.||:.:
Zfish   816 ------EINSPN--LLRMIRHTTNLTLWLEKCIVETENVEERVSVVSRIIEILQVFQELNNFNGV 872

  Fly   548 KAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDH 612
            ..::||:||:.:|||...:|.:|..:.::..| |:..||                        ||
Zfish   873 LEVVSAMNSSPVYRLDHTFEQIPSRQRKILEE-AHELSE------------------------DH 912

  Fly   613 SDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTEN--KLINFDKKRKEFEVLAQI 675
            ..::|.||     ...:...:|:.|.:||::......|||:|..:  :||||.|:||..|:..:|
Zfish   913 YKKYLAKL-----RSINPPCVPFFGIYLTNILKTEEGNPDFLKRHGTELINFSKRRKVAEITGEI 972

  Fly   676 KLLQGAANTYNLQAD-----------------ALFDHWFNSMPVFDEREAFEL-------SCRLE 716
            :..|.......::.|                 ...|:.||.....:.|.|..|       ||.|:
Zfish   973 QQYQNQPYCLRVENDIRKFFENLNPMEDMMEKEFTDYLFNKSLEIEPRNARTLPRFAKKYSCPLK 1037

  Fly   717 PP---PPAPRKSVVSTNTSLTN-------------TTASSTASIMGHRKTDSIHSNSSSGAGSQF 765
            .|   |.|.|...:...|.|.|             .|.||.||.....:|......:|  |.|..
Zfish  1038 SPGVRPSAVRPGAMRHPTPLQNEPRKISYSRIPDSETESSAASAPNSPRTPLTPPPAS--AASTD 1100

  Fly   766 YCELNSSTSSRHNSLDRDVHHQHASLMSA---------SSSVSNL 801
            .|.:..|.....:..     |.::..:.|         |||||::
Zfish  1101 TCSVFDSPQQPSSPF-----HSNSECVFAPVALPHGPRSSSVSSM 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	32/139 (23%)
		RasGEF	454..719	CDD:214539	70/303 (23%)
		RA_RalGDS_like	858..946	CDD:340449
sos1	NP_001428581.1	None