DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rgl and rasgrf2b

DIOPT Version :10

Sequence 1:NP_001261814.1 Gene:Rgl / 44115 FlyBaseID:FBgn0026376 Length:973 Species:Drosophila melanogaster
Sequence 2:XP_009300046.1 Gene:rasgrf2b / 553520 ZFINID:ZDB-GENE-060504-1 Length:1275 Species:Danio rerio


Alignment Length:723 Identity:148/723 - (20%)
Similarity:240/723 - (33%) Gaps:242/723 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   197 EEHEKNAIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGEL 261
            ||:.|..:..:.....|.|:       |..|........:.:|..::.|::.||:|.| ||...|
Zfish   597 EENSKVTVPHMIKSDARLHK-------DDVDICFSKTLNSCKVPQIRYASVERLLERL-TDLRFL 653

  Fly   262 ESTFINVFLSTYRTFSTPKQVLSLLTQRY----------------DAL----------------- 293
            ...|:|.||.|||.|:|...|:..|...|                |.|                 
Zfish   654 SIDFLNTFLHTYRIFTTATVVMEKLADIYKKPFTSIPVRVQYHSFDRLSITSICPDYSLKIRKIA 718

  Fly   294 --HEKHLEELEQAQQNGQ----------------------------------------------- 309
              ..|.||......||.:                                               
Zfish   719 LDQSKSLELFFATNQNNRSGDHVNDKSPRLCRKFSSPPPLSISSRTSSPVRTRKLSLNSPIGSKV 783

  Fly   310 -VMD----------------PAYDPHASIHEQHKKTLVSALHVWLDGFPEDWH---EDNLQ--QI 352
             ::|                |...|..|.:..:.|..:..........||...   :||.:  :|
Zfish   784 GILDLSTTSSSAASSPTSANPTISPPPSNNNNNSKPPLDLSRGQSPSSPEQSPGALDDNAEVPRI 848

  Fly   353 LAFATKRLKRSDLHIKVLN--RLERLIKQSLYGNGGG------------------SG--GSENN- 394
            .|...| |:|| :...||.  .|::.|.:|...:..|                  ||  .:||: 
Zfish   849 DALCGK-LRRS-IRRAVLESVSLDKFIPESPQASEPGEISPCRSPSTPRHLRYRQSGVQTAENSR 911

  Fly   395 ----------------GHSWLSAARSQQM---QQFMIP-----------THYGSSYDLTDQFNGM 429
                            |||......:.:.   ::|:|.           .|:.|.:....:.||.
Zfish   912 CSVSPASAFAIATAAAGHSSPPVFNNSERTCDKEFIIRRAATNRVLNVLRHWVSKHSQDFEMNGE 976

  Fly   430 YLSPMG----HGPIYRGP----------THFLQAFR-------------------------FPHV 455
            .  .||    ...:.|.|          .:.|.|..                         |..:
Zfish   977 L--KMGVICLLEEVLRDPDLLPQERKATANILSALSQDDQDDAQLKIEDILQMAECPKAECFESL 1039

  Fly   456 PVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRD-SGGSETVVATINQFNAVLFRVVSSILIDRL 519
            .....|||:|.:|..:|:.:...:.||..|.:.| :..:..::.|...||. :..:|:|.::...
Zfish  1040 SAMEIAEQITLLDHIVFRSIPYEEFLGQGWMKTDKTERTPYIMKTSQHFND-MSNLVASQIMSHT 1103

  Fly   520 KPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANIC 584
            ....||.:|.:|:.:|...|.|.|::.:..|.||||.::||||.|.|..:.|:...:..:|....
Zfish  1104 DVGSRAGSIEKWVAVADICRCLNNYNGVLEITSALNRSAIYRLKKTWAKVCKQTKALMDKLQKTV 1168

  Fly   585 SEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTA 649
            |.:.....|||      |.||.:|                      ..:||||.:||||..|...
Zfish  1169 SSEGRFKNLRE------TLKNCNP----------------------PCVPYLGMYLTDLAFIEEG 1205

  Fly   650 NPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQ-ADALFDHWFNSMPVFDEREAFELSC 713
            .|:: ||..|:||.|.|....::.:|:..|  ...|.:: ...:..:..:...:.||...::||.
Zfish  1206 TPNF-TEEGLVNFSKMRMISHIIREIRQFQ--QTPYRIEHQPKVTQYLLDKTLIMDEDTLYDLSL 1267

  Fly   714 RLEPPPPA 721
            ::||..||
Zfish  1268 KIEPRLPA 1275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RglNP_001261814.1 REM 246..378 CDD:100121 44/237 (19%)
RasGEF 454..719 CDD:214539 70/266 (26%)
RA_RalGDS_like 858..946 CDD:340449
rasgrf2bXP_009300046.1 PH_RasGRF1_2 19..154 CDD:270081
RhoGEF 243..424 CDD:214619
PH 476..583 CDD:459697
RasGEF_N 634..>682 CDD:459873 19/48 (40%)
REM <938..1010 CDD:470601 12/73 (16%)
RasGEF 1036..1272 CDD:214539 70/267 (26%)
Blue background indicates that the domain is not in the aligned region.

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