Protein Alignment Rgl and RAPGEF6

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001157858.1
• Gene: RAPGEF6 / 51735
• HGNCID: 20655
• Length: 1609
• Species: Homo sapiens
• Alignment Length: 1014
• Identity: 189/1014 - (18%)
• Similarity: 307/1014 - (30%)
• Gaps: 426/1014 - (42%)

  Fly   211 KVRYHRPTPTASNDSDDEI----SHLEWE---TVRVRFVKAATLARLVEALATDDGELESTFINV 268
            ::..|....|...:.:.||    .|.|.:   |.:...|..||..||:..|..:...::.|:|..
Human   378 RILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIED 442

  Fly   269 FLSTYRTF-STPKQV-LSLLTQ-RYDALHEK------------------------HLEE----LE 302
            ||.||||| .:|..| :.||.. :.|:|.:|                        .|||    ||
Human   443 FLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLE 507

  Fly   303 QAQQNG--QVMDPAYDPHASIHE--QHKKTLVSALHVWLDGFPE--------------------- 342
            ..:.||  ::::.|....|...:  ..|.:..|.|...|:|..|
Human   508 DTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGL 572

  Fly   343 -------DWHEDNLQQI----------------------------LAFATKRLKRSDLHIKVL-- 370
                   :.:..|.:.|                            |.|.|::.|....||..:
Human   573 KRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAE 637

  Fly   371 ------------------------------------NRLERLIKQS--------LYGNGGGSG-- 389
                                                |::.:::.::        |:.:||.|.
Human   638 KKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQ 702

  Fly   390 -----GSENNGHS--------WLSAARSQQMQQFMIPTHYGSSYDLTDQ---------------- 425
                 |:.:..||        .||::....:|.......:.:..|:.||
Human   703 DDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIII 767

  Fly   426 ----------FNGMY-----------------LSPMGHGPIYRGPTHF----------------- 446
                      |:.::                 ::|.|.....|.|..|
Human   768 SKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKN 832

  Fly   447 ---------------------LQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDS 490
                                 |...:...:.|   |.||:..|.:||:.:.|.:.:...:.....
Human   833 NMETETLCSDEDAQELVKESQLSMLQLSTIEV---ATQLSMRDFDLFRNIEPTEYIDDLFKLNSK 894

  Fly   491 GGSETVVATINQFNAVLFRVVSSILID--RLKPQERALNISRWIDIAQELRMLKNFSSLKAIISA 553
            .|:..:....:..|...|.|.|.||.:  :||   |...|..:|.||...|..|||:|:.||||.
Human   895 TGNTHLKRFEDIVNQETFWVASEILTEANQLK---RMKIIKHFIKIALHCRECKNFNSMFAIISG 956

  Fly   554 LNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQ 618
            ||..|:.||...||.||.:..:...:|.:|.....|....|.:|               |.:.:|
Human   957 LNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNIL---------------SSQSMQ 1006

  Fly   619 KLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQI-------- 675
            ..|           ||.......|:|.:|..|...:  :.|:||:|.|...:.:.|:
Human  1007 PPI-----------IPLFPVVKKDMTFLHEGNDSKV--DGLVNFEKLRMISKEIRQVVRMTSANM 1058

  Fly   676 -----------------KLLQGAANTYN-----------------LQADALFD---------HWF 697
                             .|.||:.|:..                 |.|..|::         .:.
Human  1059 DPAMMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYL 1123

  Fly   698 NSMPVFDEREAFE-LSCRLEPP-------------------PPAPRKSVVST------------- 729
            :|:.|..:.|.|: :|.:.||.                   .|.|.:|...|
Human  1124 SSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQ 1188

  Fly   730 -----------------------NTSLTNTTASSTASIMGHRKTD-------SIHSN---SSSGA 761
                                   ||||......:|..|.|.:.|:       |:||:   |..|:
Human  1189 VLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGS 1253

  Fly   762 GSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLDSSNSG-------------GRQS 813
            ..:.|..:.|:.|      |......|:.:.|.||.|||.|:||.::.             ...:
Human  1254 PHKGYTLIPSAKS------DNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPEST 1312

  Fly   814 G---KLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPS 849
            |   |..|:..:|:. ..||.|.|          |::||
Human  1313 GALEKTEHASGIGDH-SQHGPGWT----------LLKPS 1340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	44/260 (17%)
		RasGEF	454..719	CDD:214539	74/337 (22%)
		RalGDS_RA	858..946	CDD:176351
RAPGEF6	NP_001157858.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		CAP_ED	37..>82	CDD:294041
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..250
		Crp	274..>448	CDD:223736	18/69 (26%)
		CAP_ED	280..380	CDD:237999	0/1 (0%)
		RasGEFN	412..525	CDD:214571	30/112 (27%)
		PDZ_signaling	529..609	CDD:238492	8/79 (10%)
		UBQ	749..833	CDD:294102	8/83 (10%)
		RasGEF	857..1081	CDD:238087	62/257 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1200..1282		19/87 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1310..1332		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1463..1486
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1579..1609

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810