DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and CG4853

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	147/740 - (19%)
Similarity:	253/740 - (34%)	Gaps:	228/740 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RQQQQQQQDAKDSKRHYHHHTCPRQRKKSMTPVEPTHLCQKHQEAKQRRSRSASAKPR--RNSSY 136
            |..|...:...::|.:::|.:   .:|:...||       |.|.|..|.:...:.|.|  .||::
  Fly   105 RNGQILDERTVETKENFNHQS---HQKEIWHPV-------KQQSALARATPENALKYRTTSNSTF 159

  Fly   137 HSY----DDLDV------------SSAVLNAERKVVASLKYLCACTGATLRNLSKKTKDLHAKNY 185
            .|.    |:..|            :::::::...:..|.:.:.:.:..|:.:.|.......:.:
  Fly   160 ASQATDSDERPVDPLGRQLNQTFSNASLMSSSSAITGSDQVIGSVSSTTIGDKSSNISSCDSGH- 223

  Fly   186 TYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPT----------ASNDSDDEIS----HL---- 232
                            :.:|........:..|..|          :|.|..|.:|    ||
  Fly   224 ----------------DGLFHSVSMSAPWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITE 272

  Fly   233 --EWETVRV---RFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDA 292
              :.:|..|   ...|...|..:|..|..::.: :..|  .||:|.|.||.|.|:||.:..:.|.
  Fly   273 PFDCQTAPVYAKDIPKKGNLDSVVNLLINNNTK-DLRF--AFLTTSRLFSPPHQLLSKIIAKIDN 334

  Fly   293 LHEKHLEELEQAQQNGQVMDPA---YDPHASIHEQHKKTLVSALHVWLDGFPE---DWHEDNLQQ 351
            ..|..|..|      .:.:|..   :.....:.|...|..|..|..:|||.|:   ...|:...|
  Fly   335 EEENVLRLL------NEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQ 393

  Fly   352 ILAFATKRLKRSDL----HIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMI 412
            :....||:...|.|    .||.|.|....:.:           ::|                  :
  Fly   394 LNNLLTKQSSASSLGRQSSIKSLKRFAANVYK-----------TDN------------------V 429

  Fly   413 PTHYGSSYDLTDQFNGM---YLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKR 474
            ..:..|:::|..|...:   |||                     .:.:..|.|.|.:.:.:
  Fly   430 LNNCSSAFELAHQLYAIEYAYLS---------------------QIRLEEFVEILEKDELK---- 469

  Fly   475 LIPHQCLGHTWARRDSGGSE-----TVVATINQFNAVLFRVVSSILIDRL-KPQERALNISRWID 533
                .|:..|  :..:.||.     |:.:.:..||.:.:...:.||  :| |..:||..|..|::
  Fly   470 ----TCISQT--KAGTLGSNCISQVTIDSYVQWFNQLSYLTATEIL--KLGKKSQRAQMIDFWVE 526

  Fly   534 IAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLK 598
            .|.|.....||:||.||::|||..:|.||.|.|..:                         :..|
  Fly   527 TALECFNTGNFNSLMAILTALNLTAIARLKKTWAKV-------------------------QTTK 566

  Fly   599 REGTAKNPDPGSDHSD-RHLQKLIL-----NLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTE- 656
            .||.....||.|:..: |...|..:     .:..:.....||:...||.||   |..|..:.|:
  Fly   567 FEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDL---HAINESHETKL 628

  Fly   657 -NKLINFDK--------------KRKE--FEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVFD 704
             |..|||:|              :|.:  :|.|..:.       :|.|:|:           |..
  Fly   629 ANGYINFEKCLHLGTQLRNFGKWQRLDCPYEQLPSVV-------SYLLKAE-----------VLS 675

  Fly   705 EREAFELSCRLEPPPPAPRKSVVST 729
            |....:.|...|||.....|....|
  Fly   676 EDLLMKASYESEPPETGEEKDHYKT 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	37/141 (26%)
		RasGEF	454..719	CDD:214539	67/294 (23%)
		RalGDS_RA	858..946	CDD:176351
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	21/85 (25%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	60/260 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940