Protein Alignment Rgl and Rapgef5

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001382072.1
• Gene: Rapgef5 / 362799
• RGDID: 1561668
• Length: 880
• Species: Rattus norvegicus
• Alignment Length: 609
• Identity: 126/609 - (20%)
• Similarity: 216/609 - (35%)
• Gaps: 178/609 - (29%)

  Fly   209 LKKVRYHRPTPTASNDSDDEISHLEWETVRVRF-VKAATLARLVEALATD-------DGELESTF 265
            ||||....|.||..:...|           .|: |.:.|..:::|.|..|       ..|.| |.
  Rat   348 LKKVASCGPAPTTGSAESD-----------ARYVVVSGTPEKILEHLLNDLHLAEVQHKETE-TL 400

  Fly   266 INVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLV 330
            ::.||.||..|.|...:...|.:.|.|      ::.:..::|..|  |.          .|:.::
  Rat   401 LDDFLLTYTVFMTTDDLCQALLRHYSA------KKYQGEEENSDV--PC----------RKRKVL 447

  Fly   331 SALHVWLDGFPEDW-HEDNLQQILAFATKRLKRSDLH-----IKVLNRLERL------------- 376
            ..:..|:..: :|| |||...::......|....|::     .|.|...:::
  Rat   448 HLVSQWISLY-KDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYS 511

  Fly   377 -------------IKQSLYGNGGGSGGSEN-------NGHSWLS----------------AARSQ 405
                         :|::...:.|....:|.       ..||::|                |.:.|
  Rat   512 PQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYVTEHSYISVKAKVSSTAQEILKVVAEKLQ 576

  Fly   406 QMQQ--------FMIPTH-------------------YGSSYDLTDQFNGMYLSPMGHGPIYRGP 443
            :.::        |....|                   |....||.|..|          |.....
  Rat   577 RAEEDLALVAIMFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTLN----------PFAENE 631

  Fly   444 THFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETVVAT--INQFNAV 506
            ....::.|...:.....|.:|...|..||..:...:.:..|::|:.| |..||..:  :.:.|.|
  Rat   632 ESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFTFSRQGS-GEHTVNLSLLLQRCNEV 695

  Fly   507 LFRVVSSILI-DRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLP 570
            ...|.:.||: .:|  .:|...:.::|.||...:..:|.:|..||:..||:.|:.|||:.||.:|
  Rat   696 QLWVATEILLCSQL--GKRVQLVKKFIKIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIP 758

  Fly   571 KERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPY 635
            .:..::|:||.::.....|....|:..|:....|                            ||:
  Rat   759 GKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPK----------------------------IPF 795

  Fly   636 LGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADAL------FD 694
            :...|.|:|.||..|..:|  :.|:||:|    ..::|..........|....:|..      ..
  Rat   796 MPLLLKDVTFIHEGNKTFL--DNLVNFEK----LHMIADTVRTLRHCRTNQFGSDMSPKEQQELK 854

  Fly   695 HWFNSMPVFDEREA-FELSCRLEP 717
            .:.|.:.|.|.::| ||||.||||
  Rat   855 SYVNHLYVIDSQQALFELSHRLEP 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	30/170 (18%)
		RasGEF	454..719	CDD:214539	69/274 (25%)
		RalGDS_RA	858..946	CDD:176351
Rapgef5	NP_001382072.1	DEP_Epac	98..221	CDD:239884
		RasGEFN	368..499	CDD:214571	32/150 (21%)
		RasGEF	640..879	CDD:214539	69/276 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810