DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and Rasgef1c

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001101743.1	Gene:	Rasgef1c / 360519	RGDID:	1311549	Length:	466	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	118/541 - (21%)
Similarity:	197/541 - (36%)	Gaps:	154/541 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 AATLARLVEALA-TDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQN 307
            :|:|..|::.|. |.|...|..:|..||.:.|.|..|:::|:.:.         || .:||.|.:
  Rat    40 SASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVC---------HL-CIEQQQLD 94

  Fly   308 GQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNR 372
            ..|:|     .|.:.:...| |:..|..|.:.||.|:.|::....|.....|:...|
  Rat    95 KPVLD-----KARVRKFGAK-LLQLLAEWTETFPRDFEEESTIGHLTDVVGRISPCD-------- 145

  Fly   373 LERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHG 437
                   ..|||                     :|.|.:...|             ..|:.:|.|
  Rat   146 -------ETYGN---------------------RMHQLLQTLH-------------QKLASLGQG 169

  Fly   438 P-------------------IYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGH 483
            |                   |:|   ..|.....|:.    .|:|||.::.|..:.:.|.:.: .
  Rat   170 PEGLVGADKPISYRTKPPASIHR---ELLGVCSDPYT----LAQQLTHVELERLRHIGPEEFV-Q 226

  Fly   484 TWARRD---------SGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELR 539
            .:..:|         :..:..|.|.:..||.:.:.|.:.|.:. .|.::||..|..:||:|:|..
  Rat   227 AFVNKDPLAGTKPRFNDKTNNVEAYVKWFNRLCYLVATEICMP-AKKKQRAQVIEFFIDVARECF 290

  Fly   540 MLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTE----LANICSEDNNAWTLREVLKRE 600
            .:.||:||.||||.:|.:.:.||.|.|..:...:..:...    ..|.|   |....||....|.
  Rat   291 NIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFFILEHQMDPTGNFC---NYRTALRGAAHRS 352

  Fly   601 GTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKK 665
            .||        ||.|  :|::           ||:....:.|:..::....:.| .|..:||:
  Rat   353 LTA--------HSSR--EKIV-----------IPFFSLLIKDIYFLNEGCANRL-PNGHVNFE-- 393

  Fly   666 RKEFEVLAQIKLLQGAANTYN-----LQADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRKS 725
             |..|:..|:    |...|:.     .:.|....|:..:.|:|.|...:..|...|.|
  Rat   394 -KFLELAKQV----GEFITWKQVECPFEQDPSITHYLYTAPIFSEDGLYLASYESESP------- 446

  Fly   726 VVSTNTSLTNTTASSTASIMG 746
               .|.:......|..:||:|
  Rat   447 ---ENQTEKERWKSLRSSILG 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	32/132 (24%)
		RasGEF	454..719	CDD:214539	65/282 (23%)
		RalGDS_RA	858..946	CDD:176351
Rasgef1c	NP_001101743.1	REM	42..163	CDD:100121	38/185 (21%)
Rasgef1c	NP_001101743.1	RasGEF	200..447	CDD:214539	67/294 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910